Reference : High Prevalence of Plasmodium falciparum Infection in Asymptomatic Individuals from t...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/201063
High Prevalence of Plasmodium falciparum Infection in Asymptomatic Individuals from the Democratic Republic of the Congo
English
[en] Forte prévalence de l'infection à Plasmodium falciparum en RDC
[en] Forte prévalence de l'infection à Plasmodium falciparum chez des sujets asymptomatiques en RDC
Mvumbi, Dieudonné mailto [School of Medicine, University of Kinshasa, P.O. Box Kin XI > Biochemistry and Molecular Biology Unit, Department of Basic Sciences > > >]
Bobanga, Thierry [UNIKIN > > > >]
Melin, Pierrette mailto [Université de Liège > Département des sciences biomédicales et précliniques > Bactériologie, mycologie, parasitologie, virologie >]
De Mol, Patrick mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Kayembe, Jean-Marie [Université de Kinshasa > > > >]
Situakibanza, Hippolyte [UNIKIN > Department of Parasitology and Tropical Medicine, > > >]
Mvumbi, Georges mailto [University of Kinshasa > 1Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa > > >]
Nsibu, Célestin [> >]
Umesumbu, Solange [> >]
Hayette, Marie-Pierre mailto [Université de Liège > Département des sciences biomédicales et précliniques > Bactériologie, mycologie, parasitologie, virologie >]
Jan-2016
Malaria Research and Treatment
2016
Yes (verified by ORBi)
International
2044-4362
[en] Plasmodium falciparum ; asymptomatic carriers ; RDC ; malaria
[en] Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHOMalaria Report in 2014. Asymptomaticmalaria cases are known to be prevalent in endemic areas and are generally untreated,resulting in a significant source of gametocytes that may serve as reservoir of disease transmission. Considering that microscopycertainly underestimates the prevalence of Plasmodium infections within symptomatic carriers and that PCR assays are currentlyrecognized as the most sensitive methods for Plasmodium identification, this study was conducted to weigh the asymptomatic
carriage in DRC by a molecular method. Six provinces were randomly selected for blood collection in which 80 to 100 individuals were included in the study. Five hundred and eighty blood sampleswere collected andmolecular diagnosiswas performed. Globally, almost half of the samples collected from asymptomatic individuals (280/580; 48.2%) had Plasmodium infections and the most species identified was P. falciparum alone in combination with P. malariae. The high prevalence reported here should interpellate the bodies involved in malaria control in DR Congo to take into account asymptomatic carriers in actions taken and consider asymptomatic malaria as a major hurdle for malaria elimination.
Commission universitaire pour le Développement - CUD
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/201063
10.1155/2016/5405802
http://dx.doi.org/10.1155/2016/5405802

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