Reference : Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human G...
Scientific journals : Article
Human health sciences : Dentistry & oral medicine
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Engineering, computing & technology : Materials science & engineering
Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Fibroblasts (HGFs).
GRENADE, Charlotte mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service prothèse fixée >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Gailly, Patrick mailto [Université de Liège > > CSL (Centre Spatial de Liège) >]
Vanheusden, Alain mailto [Université de Liège > Département de sciences dentaires > Prothèse dentaire fixe - Anatomie bucco-dentaire >]
Mainjot, Amélie mailto [Université de Liège > Département de sciences dentaires > Biomatériaux dentaires >]
Dental Materials
Yes (verified by ORBi)
[en] Biocompatibility ; CAD-CAM composite ; Dental implant prostheses ; Human gingival fibroblasts ; Lithium disilicate glass-ceramic ; Polymer infiltrated ceramic network ; Titanium ; Zirconia
[en] OBJECTIVES: Polymer-infiltrated-ceramic-network (PICN) materials constitute an innovative class of CAD-CAM materials offering promising perspectives in prosthodontics, but no data are available in the literature regarding their biological properties. The objective of the present study was to evaluate the in vitro biocompatibility of PICNs with human gingival fibroblasts (HGFs) in comparison with materials typically used for implant prostheses and abutments. METHODS: HGF attachment, proliferation and spreading on discs made of PICN, grade V titanium (Ti), yttrium zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control), were evaluated using a specific insert-based culture system (IBS-R). Sample surface properties were characterized by XPS, contact angle measurement, profilometry and SEM. RESULTS: Ti and Zi gave the best results regarding HGF viability, morphology, number and coverage increase with time in comparison with the negative control, while PICN and eM gave intermediate results, cell spreading being comparable for PICN, Ti, Zi and eM. Despite the presence of polymers and their related hydrophobicity, PICN exhibited comparable results to glass-ceramic materials, which could be explained by the mode of polymerization of the monomers. SIGNIFICANCE: The results of the present study confirm that the currently employed materials, i.e. Ti and Zi, can be considered to be the gold standard of materials in terms of HGF behavior, while PICN gave intermediate results comparable to eM. The impact of the present in vitro results needs to be further investigated clinically, particularly in the view of the utilization of PICNs for prostheses on bone-level implants.
Copyright (c) 2016 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

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