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Article (Scientific journals)
Neurotrophic effects of BDNF and CNTF, alone and in combination, on postnatal day 5 rat acoustic ganglion neurons.
Hartnick, C. J.; Staecker, H.; Malgrange, Brigitte et al.
1996In Journal of Neurobiology, 30 (2), p. 246-54
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Keywords :
Animals; Auditory Pathways/drug effects; Brain-Derived Neurotrophic Factor/pharmacology; Cell Survival/drug effects; Cells, Cultured; Ciliary Neurotrophic Factor; Drug Therapy, Combination; Ganglia, Sensory/cytology/drug effects; Nerve Growth Factors/pharmacology; Nerve Tissue Proteins/pharmacology; Neurites/drug effects; Rats
Abstract :
[en] The neuronal survival promoting ability of brain derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF), individually and in combination, was evaluated in dissociated cell cultures of postnatal day 5 (P5) rat acoustic ganglia. The neuritogenic promoting effect of these same neurotrophic factors was examined in organotypic explants of P5 rat acoustic ganglia. The results showed that BDNF was maximally effective at a concentration of 10 ng/mL in promoting both survival and neuritogenesis of these postnatal auditory neurons in vitro. CNTF was maximally effective at a concentration of 0.01 ng/mL at promoting both survival and neuritogenesis in the acoustic ganglion cultures. BDNF had its strongest effect on neuronal survival while CNTF was most effective in stimulating neurite outgrowth. These two neurotrophic factors, when added together at their respective maximally effective concentrations, behave in an additive manner for promoting both survival and neuritic outgrowth by the auditory neurons.
Disciplines :
Otolaryngology
Author, co-author :
Hartnick, C. J.
Staecker, H.
Malgrange, Brigitte  ;  Université de Liège > GIGA - Neurosciences
Lefèbvre, Philippe ;  Université de Liège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Liu, W.
Moonen, Gustave  ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Van de Water, T. R.
Language :
English
Title :
Neurotrophic effects of BDNF and CNTF, alone and in combination, on postnatal day 5 rat acoustic ganglion neurons.
Publication date :
1996
Journal title :
Journal of Neurobiology
ISSN :
0022-3034
eISSN :
1097-4695
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Volume :
30
Issue :
2
Pages :
246-54
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 August 2016

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