Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro.

Lefèbvre, Philippe; Malgrange, Brigitte; Staecker, H.; Moghadass, M.; Van de Water, T. R.; Moonen, Gustave

doi:10.1097/00001756-199404000-00003

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Article (Scientific journals)

Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro.

Lefèbvre, Philippe; Malgrange, Brigitte; Staecker, H. et al.

1994 • In Neuroreport, 5 (8), p. 865-8

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/200726

DOI
10.1097/00001756-199404000-00003

PubMed
8061284

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Keywords :

Animals; Brain-Derived Neurotrophic Factor; Cell Survival/drug effects; Cells, Cultured; Cochlear Nucleus/drug effects/metabolism; Molecular Weight; Nerve Growth Factors/biosynthesis/pharmacology; Nerve Tissue Proteins/biosynthesis/pharmacology; Neurites/drug effects/ultrastructure; Neurons, Afferent/drug effects/ultrastructure; Neurotrophin 3; Polymerase Chain Reaction; Rats; Rats, Wistar; Vestibulocochlear Nerve/cytology; Vestibulocochlear Nerve Injuries

Abstract :

[en] This study evaluates the trophic effects of three neurotrophins on traumatized adult auditory neurons in culture, and the presence of these neurotrophins in cochlear nucleus tissue. BDNF and NT-3 promoted survival but very limited neuritogenesis by adult auditory neurons in vitro, while NGF, although without a survival effect, evoked a robust neuritic outgrowth response when combined with BDNF. Messenger RNAs that encode for NGF, BDNF and NT-3 were detected by RT-PCR in RNA extracts from adult cochlear nuclei tissue. Based on these in vitro and in vivo findings, we propose NT-3 as the agent of the peripheral target-derived survival promoting effect and NGF, BDNF, and NT-3 as mediators of trophic influences originating from the central target (i.e. cochlear nucleus).

Disciplines :

Otolaryngology

Author, co-author :

Lefèbvre, Philippe ; Université de Liège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie

Malgrange, Brigitte ; Université de Liège > GIGA - Neurosciences

Staecker, H.

Moghadass, M.

Van de Water, T. R.

Moonen, Gustave ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro.

Publication date :

1994

Journal title :

Neuroreport

ISSN :

0959-4965

eISSN :

1473-558X

Publisher :

Lippincott Williams & Wilkins, United States

Volume :

Issue :

Pages :

865-8

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 August 2016

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