Reference : Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability.
Scientific journals : Article
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/200694
Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability.
English
Frenz, Christopher M [> > > >]
Lefèbvre, Philippe mailto [Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
2008
International Journal of Computational Biology and Drug Design
1
3
295-301
Yes
International
1756-0756
England
[en] cochlea
[en] The POU4F3 transcription factor is expressed in the cochlear and vestibular hair cells of the inner ear and its targeted deletion results in a loss of inner ear hair cells. The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. Molecular modelling is utilised to propose a mechanism of stability enhancement, via an interaction between the truncated POU(HD) domain and the POU(S) domain of the transcription factor.
http://hdl.handle.net/2268/200694

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