[en] The POU4F3 transcription factor is expressed in the cochlear and vestibular hair cells of the inner ear and its targeted deletion results in a loss of inner ear hair cells. The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. Molecular modelling is utilised to propose a mechanism of stability enhancement, via an interaction between the truncated POU(HD) domain and the POU(S) domain of the transcription factor.
Disciplines :
Otolaryngology
Author, co-author :
Frenz, Christopher M
Lefèbvre, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Language :
English
Title :
Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability.
Publication date :
2008
Journal title :
International Journal of Computational Biology and Drug Design
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