[en] OBJECTIVE: To analyse the relationship between the levels of urinary biochemical markers of type II collagen degradation and the clinical and radiological severity and progression of knee osteoarthritis (OA). METHOD: Seventy-five patients with primary knee OA were included in this 3-year follow-up study. Mean joint space width (JSW) of the medial compartment of the femorotibial joint was measured with a computer assisted method on standardized radiographs taken at baseline and after a 3-year follow-up. Pain, stiffness, and physical function subscales of the Western Ontario and McMaster Universities (WOMAC) were assessed at the same time points. Type II collagen peptides Coll 2-1 and Coll 2-1 NO(2), as well as pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) were measured in urines at baseline, after 1 year and 3 years, with specific immunoassays. RESULTS: At baseline, significant correlations were found between the urinary Coll 2-1 and Coll 2-1 NO(2) levels and the global WOMAC score (Coll 2-1: r=0.28, P=0.01; Coll 2-1 NO(2): r=0.27, P=0.02) and its subscales for pain (Coll 2-1: r=0.27, P=0.01; Coll 2-1 NO(2): r=0.30, P=0.01) and function (Coll 2-1: r=0.29, P=0.01; Coll 2-1 NO(2): r=0.27, P=0.02). Pyr and D-Pyr levels were not significantly correlated with the WOMAC scores. One-year change in Coll 2-1 and Coll 2-1 NO(2) urinary levels were negatively correlated with a 3-year change in JSW (Coll 2-1: r=-0.31, P=0.03; Coll 2-1 NO(2): r=-0.31, P=0.03), indicating that an increase of Coll 2-1 or Coll 2-1 NO(2) over 1 year is predictive of subsequent joint space narrowing. Neither Pyr nor D-Pyr was correlated with radiological OA progression. CONCLUSIONS: At baseline, Coll 2-1 and Coll 2-1 NO(2) urinary levels were indicative of the clinical activity of knee OA and the increase of these peptides over 1 year was predictive of the radiological progression of knee OA.
Disciplines :
Rhumatologie
Auteur, co-auteur :
Deberg, Michelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Labasse, Alain ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et physiopathologie
Collette, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Secteur dispatching
Seidel, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Non budgétaires
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie
Langue du document :
Anglais
Titre :
One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression.
M. Sharif D.J. Osborne K. Meadows S.M. Woodhouse E.M. Colvin L. Shepstone et al. The relevance of chondroitin and keratan sulphate markers in normal and arthritic synovial fluid Br J Rheumatol 35 1996 951-957
R.C. Billinghurst L. Dahlberg M. Ionescu A. Reiner R. Bourne C. Rorabeck et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage J Clin Invest 99 1997 1534-1545
L.S. Lohmander The role of molecular markers to monitor breakdown and repair, In: J.Y. Reginster, J.-P. Pelletier, J. Martel-Pelletier, Y. Henrotin Eds. Osteoarthritis: Clinical and Experimental Aspects 1999 Springer-Verlag Berlin 297-311
P. Garnero M. Piperno E. Gineyts S. Christgau P.D. Delmas E. Vignon Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage Ann Rheum Dis 60 2001 619-626
M. Deberg S. Christgau P. Cloos D.B. Henriksen C. Sanchez A. Labasse et al. Development of new immunoassays for the quantification of inflammatory related cartilage degradation Arthritis Rheum 46 2002 S496
P. Garnero X. Ayral J.C. Rousseau S. Christgau L. Sandell M. Dougados et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis Arthritis Rheum 46 2002 2613-2624
V. Vilim M. Olejarova S. Machacek J. Gatterova V.B. Krauss K. Pavelka Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis Osteoarthritis Cartilage 10 2002 707-713
O. Bruyère J. Collette O. Etghen L. Rovati G. Giacovelli Y. Henrotin et al. Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis J Rheumatol 30 2003 1043-1050
D.R. Eyre T.J. Koob K.P. Van Ness Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography Anal Biochem 137 1984 380-388
D. Fujimoto M. Suzuki A. Uchiyama S. Miyamoto T. Inoue Analysis of pyridinoline, a cross-linking compound of collagen fibers in human urine J Biochem 94 1983 1133-1136
M. Bonde P. Qvist C. Fledelius B.J. Riis C. Christiansen Immunoassay for quantifying type I collagen degradation products in urine evaluated Clin Chem 40 1994 2022-2025
P.W. Thompson T.D. Spector I.T. James E. Henderson D.J. Hart Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis Br J Rheumatol 31 1992 759-761
L.J. Croucher A.P. Hollander Differential detection of type II collagen N-terminal and C-terminal denaturation epitopes in degrading cartilage J Clin Pathol: Mol Pathol 52 1999 323-331
M. Roy-Beaudry J. Martel-Pelletier J.P. Pelletier K.N. M'Barek S. Christgau F. Shipkolye et al. Endothelin 1 promotes oteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction Arthritis Rheum 48 2003 2855-2864
F. Nelson L. Dahlberg S. Laverty A. Reiner I. Pidoux M. Ionescu et al. Evidence for altered synthesis of type II collagen in patients with osteoarthritis J Clin Invest 102 1998 2115-2125
S. Christgau P. Garnero C. Fledelius C. Moniz M. Ensig E. Gineyts et al. Collagen type II C-telopeptide fragments as an index of cartilage degradation Bone 29 2001 209-215
M. Jung S. Christgau M. Lukoschek D. Henriksen W. Richter Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis Pathobiology 71 2004 70-76
S. Christgau Y. Henrotin L.B. Tanko L.C. Rovati J. Collette O. Bruyere et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulfate Clin Exp Rheumatol 22 2004 36-42
P. Garnero T. Conrozier S. Christgau P. Mathieu P.D. Delmas E. Vignon Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis Ann Rheum Dis 62 2003 939-943
M. Deberg A. Labasse S. Christgau P. Cloos D.B. Henriksen J.P. Chapelle et al. New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis Osteoarthritis Cartilage 13 2005 258-265
Y. Henrotin G. Deby-Dupont C. Deby M. De Bruyn M. Lamy P. Franchimont Production of active oxygen species by isolated human chondrocytes Br J Rheumatol 32 1993 562-567
Y. Henrotin S. Zheng G. Deby A. Labasse J.M. Crielaard J.Y. Reginster Nitric oxide downregulates interleukin 1 beta (IL-1 beta) stimulated IL-6, IL-8 and prostaglandin E2 production by human chondrocytes J Rheumatol 25 1998 1595-1601
A. Van der vliet D. Smith C.A. O'Neill H. Kaur V. Darley-Usmar C.E. Cross et al. Interactions of peroxynitrite with human plasma and its constituents: Oxidative damage and antioxidant depletion Biochem J 303 1994 295-301
Y. Henrotin M. Deberg J.E. Dubuc E. Quettier S. Christgau Y. Reginster Type II collagen peptides for measuring cartilage degradation Biorheology 41 2004 543-547
R. Altman E. Asch D. Bloch G. Bole D. Borenstein Brandt et al. Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee Arthritis Rheum 29 1986 1039-1049
J.Y. Reginster R. Deroisy L.C. Rovati R.L. Lee E. Lejeune O. Bruyere et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: A randomised, placebo-controlled clinical trial Lancet 357 2001 251-256
R. Altman K. Brandt M. Hochberg R. Moskowiz N. Bellamy D.A. Bloch et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society. Results from a workshop Osteoarthritis Cartilage 4 1996 217-243
J.E. Dacre E.C. Huskisson The automatic assessment of knee radiographs in osteoarthritis using digital image analysis Br J Rheumatol 28 1989 506-510
O. Bruyère Y.E. Henrotin A. Honoré L.C. Rovati L. Seidel C. Dardenne et al. Impact of the joint space width measurement method on the design of knee osteoarthritis studies Aging Clin Exp Res 15 2003 136-141
J. Byrne G. Heald M.F. James M. Kay J. Shorter J.E. Dacre Digital image analysis, a rapid and reproducible method for joint space measurement Osteoarthritis Cartilage 1 1993 60-61
N. Bellamy W.W. Buchanan C.H. Goldsmith J. Campbell L.W. Stitt Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee J Rheumatol 15 1988 1833-1840
C. Rosenquist C. Fledelius S. Chritsgau B.J. Pedersen M. Bonde P. Qvist et al. Serum CrossLaps one step ELISA. First application of monoclonal antibodies for measurements in serum of bone-related degradation products from C-terminal telopeptides of type I collagen Clin Chem 44 1998 2281-2289
M. Jaffé Ueber den niederschlag welchen picrinsaure in normalen harn erzeugt und uber eine neue reaction des kreatinins Hoppe Seylers Z Physiol Chem 10 1986 391-400
