[en] Around 30 to 50 % of obese subjects are « metabolically normal » (MHO) whereas numerous non obese subjects are « metabolically abnormal ». The distribution and the function of adipose depots seem to play a crucial role to explain this apparent discrepancy. In a first paper, we described the clinical and biological characteristics of these MHO individuals, analyzed the underlying pathophysiological mechanisms, and reported the prevalence of this syndrome in the adult population. This second paper aims at assessing the prognosis, especially regarding the risk of diabetes and cardiovascular disease, and at discussing the advantages and disadvantages of a classical therapeutic strategy of obesity among MHO individuals. [fr] Environ 30 à 50 % des sujets sont « métaboliquement sains » bien qu’ils soient obèses (MHO pour « Metabolically Healthy, but Obese ») alors qu’inversement, nombre de sujets non obèses sont « métaboliquement anormaux ». La topographie et la fonction des dépôts graisseux semblent jouer un rôle déterminant pour expliquer cette apparente discordance. Nous avons décrit dans un premier article les caractéristiques cliniques, les mécanismes physiopathologiques et la prévalence du syndrome MHO dans la population adulte. Ce second article a pour objectifs d’évaluer le pronostic, notamment en termes de diabète et de risque cardio-vasculaire, et de discuter les avantages et inconvénients d’une prise en charge classique de l’obésité chez ces patients MHO
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Esser, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > Service de diabétologie, nutrition, maladies métaboliques
PAQUOT, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Service de diabétologie, nutrition, maladies métaboliques
SCHEEN, André ; Centre Hospitalier Universitaire de Liège - CHU > Service de diabétologie, nutrition, maladies métaboliques
Language :
French
Title :
Sujets « métaboliquement sains », bien qu’obèses 2ème partie : pronostic et prise en charge
Alternative titles :
[en] Metabolically healthy, but obese subjects. Second part : prognosis and management
Publication date :
2009
Journal title :
Obésité: Revue Francophone pour la Recherche Clinique, la Prévention et la Prise en Charge de l'Obésité
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