magnetic resonance imaging; X-ray; osteoarthritis; structural progression
Abstract :
[en] Objective: To investigate, over 1-year, the relationship between X-ray and magnetic resonance imaging (MRI) findings in patients with knee osteoarthritis (OA). Methods: Sixty-two osteoarthritic patients (46 women) were followed for 1 year. At baseline and after 1 year, volume and thickness of cartilage of the medial tibia, the lateral tibia and the femur were assessed by MRI. A global score from the multi-feature whole-organ MRI scoring system (WORMS) was calculated for each patient at baseline and after 1 year. This score combined individual scores for articular cartilage, osteophytes, bone marrow abnormality, subchondral cysts and bone attrition in 14 locations. It also incorporated scores for the medial and lateral menisci, anterior and posterior cruciate ligaments, medial and lateral collateral ligaments and synovial distension. Lateral and medial femorotibial joint space width (JSW) measurements, performed by digital image analysis, were assessed from fixed-flexion, postero-anterior knee radiographs. Results: One-year changes in medial femoro-tibial JSW reach 6.7 (20.5) % and changes in medial cartilage volume and thickness reach 0.4 (16.7) % and 2.1 (11.3) %, respectively. Medial femoro-tibial joint space narrowing (JSN) after 1 year, assessed by radiography, was significantly correlated with a loss of medial tibial cartilage volume (r = 0.25, P = 0.046) and medial tibial cartilage thickness (r = 0.28, P = 0.025), over the same period. We found also a significant correlation between the progression of the WORMS and radiographic medial JSN over 1 year (r = -0.35, P = 0.006). All these results remained statistically significant after adjusting for age, sex and body mass index. Conclusion: This study shows a moderate but significant association between changes in JSW and changes in cartilage volume or thickness in knee joint of osteoarthritic patients. (C) 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Disciplines :
Rheumatology Orthopedics, rehabilitation & sports medicine
Author, co-author :
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Felson D.T., Zhang Y., Hannan M.T., Naimark A., Weissman B.N., Aliabadi P., et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 38 10 (1995) 1500-1505
Abadie E., Ethgen D., Avouac B., Bouvenot G., Branco J., Bruyere O., et al. Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis. Osteoarthritis Cartilage 12 4 (2004) 263-268
Altman R.D., Abadie E., Avouac B., Bouvenot G., Branco J., Bruyere O., et al. Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritis. Osteoarthritis Cartilage 13 1 (2005) 13-19
Eckstein F., Schnier M., Haubner M., Priebsch J., Glaser C., Englmeier K.H., et al. Accuracy of cartilage volume and thickness measurements with magnetic resonance imaging. Clin Orthop Relat Res 352 (1998) 137-148
Ding C., Garnero P., Cicuttini F., Scott F., Cooley H., and Jones G. Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis Cartilage 13 3 (2005) 198-205
Burgkart R., Glaser C., Hyhlik-Durr A., Englmeier K.H., Reiser M., and Eckstein F. Magnetic resonance imaging-based assessment of cartilage loss in severe osteoarthritis: accuracy, precision, and diagnostic value. Arthritis Rheum 44 9 (2001) 2072-2077
Peterfy C.G., Guermazi A., Zaim S., Tirman P.F., Miaux Y., White D., et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 12 3 (2004) 177-190
Peterfy C., Li J., Zaim S., Duryea J., Lynch J., Miaux Y., et al. Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol 32 3 (2003) 128-132
Kothari M., Guermazi A., von Ingersleben G., Miaux Y., Sieffert M., Block J.E., et al. Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 14 9 (2004) 1568-1573
Duryea J., Jiang Y., Zakharevich M., and Genant H.K. Neural network based algorithm to quantify joint space width in joints of the hand for arthritis assessment. Med Phys 27 5 (2000) 1185-1194
Fernandez-Madrid F., Karvonen R.L., Teitge R.A., Miller P.R., and Negendank W.G. MR features of osteoarthritis of the knee. Magn Reson Imaging 12 5 (1994) 703-709
Boegard T., Rudling O., Petersson I.F., and Jonsson K. Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the patellofemoral joint. Ann Rheum Dis 57 7 (1998) 395-400
Link T.M., Steinbach L.S., Ghosh S., Ries M., Lu Y., Lane N., et al. Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226 2 (2003) 373-381
Cicuttini F.M., Wang Y.Y., Forbes A., Wluka A.E., and Glisson M. Comparison between patella cartilage volume and radiological assessment of the patellofemoral joint. Clin Exp Rheumatol 21 3 (2003) 321-326
Cicuttini F.M., Wluka A.E., Forbes A., and Wolfe R. Comparison of tibial cartilage volume and radiologic grade of the tibiofemoral joint. Arthritis Rheum 48 3 (2003) 682-688
Jones G., Ding C., Scott F., Glisson M., and Cicuttini F. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage 12 2 (2004) 169-174
Cicuttini F.M., Wluka A.E., Hankin J., and Stuckey S. Comparison of patella cartilage volume and radiography in the assessment of longitudinal joint change at the patellofemoral joint. J Rheumatol 31 7 (2004) 1369-1372
Raynauld J.P., Martel-Pelletier J., Berthiaume M.J., Labonte F., Beaudoin G., de Guise J.A., et al. Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes. Arthritis Rheum 50 2 (2004) 476-487
Mazzuca S.A., Brandt K.D., Buckwalter K.A., and Lequesne M. Pitfalls in the accurate measurement of joint space narrowing in semiflexed, anteroposterior radiographic imaging of the knee. Arthritis Rheum 50 8 (2004) 2508-2515
Cicuttini F.M., Jones G., Forbes A., and Wluka A.E. Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study. Ann Rheum Dis 63 9 (2004) 1124-1127
Cicuttini F., Hankin J., Jones G., and Wluka A. Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthritis Cartilage 13 8 (2005) 722-727
