[en] Purpose: The present study aimed to investigate the safety and the anti-postoperative peritoneal
adhesion (PPA) characteristics of SeprameshVR (Davol), a composite mesh made of polypropylene
covered with Seprafilm, when intraperitoneally placed in a rat model.
Methods: Twenty male rats were randomized into a control group and a Sepramesh group.
They underwent a primary surgical procedure aiming to induce a peritoneal injury in order to
induce PPAs. In the Sepramesh group, the burnt peritoneum was covered with a 2-cm diameter
disc of Sepramesh prosthesis. The mesh was fixed to the parietal peritoneum with four
3-0 absorbable stitches. PPAs were assessed during a second laparotomy 10 days later using
quantitative and qualitative scoring systems.
Results: There was no difference in terms of mean number of PPAs between both groups. All
the rats from the control group developed PPAs. In the Sepramesh group, no adhesions were
observed at the site of the injured peritoneum that had been covered with the Sepramesh
prosthesis, but PPAs occurred at the extremities of the mesh, where there was close contact
between polypropylene and viscera, or where the fixation sutures were placed. The severity
and the type of adhesions were significantly higher in the control group.
Conclusions: This study demonstrated that for the Sepramesh prostheses, the Seprafilm layer
might be effective in PPA prevention, but damage caused by the section and fixation of
Sepramesh should be limited in order to limit PPAs.
Research Center/Unit :
aCentre De Recherche Et D eveloppement En Chirurgie (CREDEC), GIGA – Cardiovascular Sciences, University of Liege (ULiège), Liege, Belgium; bDepartment of General Surgery, Cliniques Universitaires De Lubumbashi, University of Lubumbashi, Lubumbashi, Katanga Province, Democratic Republic of Congo; cAnimal Facility, GIGA-R Cardiovascular Sciences, University of Liege (ULiège), Liege, Belgium; dDepartment of Abdominal Surgery and Transplantation, CHU Liege, University of Liege (ULiège CHU), Liege, Belgium
Disciplines :
Surgery
Author, co-author :
Arung, Willy
Drion, Pierre ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
DETRY, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdo, sénologique, endocrine et de transplantation
Language :
English
Title :
Sepramesh and postoperative peritoneal adhesions in a rat model
This study was supported in part by institutional research grants from the University of Liege. Pr Willy Arung was a PhD student supported by the CTB (Cooperation Technique Belge, the Belgian Development Agency).
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