Ajioka I, Martins RAP, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. 2007. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131:378–390.
Andreu Z, Khan MA, GonzÁlez-Gómez P, Negueruela S, Hortigüela R, San Emeterio J, Ferrón SR, Martínez G, Vidal A, Fariñas I, Lie DC, Mira H. 2015. The cyclin-dependent kinase inhibitor p27(kip1) regulates radial stem cell quiescence and neurogenesis in the adult hippocampus. Stem Cells Dayton, Ohio 33:219–229.
Andrusiak MG, Mcclellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, Kennedy TE, Slack RS. 2010. Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol 31:238–247.
Andrusiak MG, Vandenbosch R, Park DS, Slack RS. 2012. The retinoblastoma protein is essential for survival of postmitotic neurons. J Neurosci 32:14809–14814.
Babu H, Cheung G, Kettenmann H, Palmer TD, Kempermann G. 2007. Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. PLoS ONE 2:e388.
Beukelaers P, Vandenbosch R, Caron N, Nguyen L, Belachew S, Moonen G, Kiyokawa H, Barbacid M, Santamaría D, Malgrange B. 2011. Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells 29:713–724.
Chen D, Chen Y, Forrest D, Bremner R. 2013. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ 20:931–940.
Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. 2004. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5:539–551.
Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger MW, Leone G, Bremner R. 2007. Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol 5:e179.
Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LML, Baker SJ, Sorrentino BP, Dyer MA. 2009. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci USA 106:6685–6690.
Clarke L, van der Kooy D. 2011. The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells. Stem Cells 29:1448–1458.
Ernst A, Frisén J. 2015. Adult neurogenesis in humans- common and unique traits in mammals. PLoS Biol 13:e1002045.
Ferguson KL, McClellan KA, Vanderluit JL, McIntosh WC, Schuurmans C, Polleux F, Slack RS. 2005. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. Embo J 24:4381–4391.
Ferguson KL, Vanderluit JL, Hébert JM, McIntosh WC, Tibbo E, MacLaurin JG, Park DS, Wallace VA, Vooijs M, McConnell SK, Slack RS. 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical Development. Embo J 21:3337–3346.
Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549–561.
Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS. 2001. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 155:207–216.
Ghanem N, Andrusiak MG, Svoboda D, Lafi Al SM, Julian LM, McClellan KA, De Repentigny Y, Kothary R, Ekker M, Blais A, Park DS, Slack RS. 2012. The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. J Neurosci 32:8219–8230.
Hébert JM, McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222:296–306.
Iaquinta PJ, Lees JA. 2007. Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol 19:649–657.
Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H, DC L. 2009. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci 29:7966–7977.
Kempermann G, Jessberger S, Steiner B, Kronenberg G. 2004. Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447–452.
Kesner RP. 2013. An analysis of the dentate gyrus function. Behav Brain Res 254:1–7.
Kowalczyk A, Filipkowski RK, Rylski M, Wilczynski GM, Konopacki FA, Jaworski J, Ciemerych MA, Sicinski P, Kaczmarek L. 2004. The critical role of cyclin D2 in adult neurogenesis. J Cell Biol 167:209–213.
Li G, Pleasure SJ. 2007. Genetic regulation of dentate gyrus morphogenesis. Prog Brain Res 163:143–152.
MacPherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T. 2003. Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol 23:1044–1053.
MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18:1681–1694.
Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14:994–1004.
Martins RAP, Davis D, Kerekes R, Zhang J, Bayazitov IT, Hiler D, Karakaya M, Frase S, Gleason S, Zakharenko SS, Johnson DA, Dyer MA. 2011. Retinoblastoma (Rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons. Proc Natl Acad Sci USA 108:21111–21116.
Mcclellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS. 2007. Unique Requirement for Rb/E2F3 in neuronal migration: Evidence for cell cycle-independent functions. Mol Cell Biol 27:4825–4843.
Naser R, Vandenbosch R, Omais S, Hayek D, Jaafar C, Lafi Al S, Saliba A, Baghdadi M, Skaf L, Ghanem N. 2016. Role of the retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb. Sci Rep 6:20230.
Oshikawa M, Okada K, Nakajima K, Ajioka I. 2013. Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner. Development 140:2310–2320.
Qiu J, Takagi Y, Harada J, Topalkara K, Wang Y, Sims JR, Zheng G, Huang P, Ling Y, Scadden DT, Moskowitz MA, Cheng T. 2009. p27Kip1Constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. Stem Cells 27:920–927.
Rolando C, Taylor V. 2014. Neural stem cell of the hippocampus: Development, physiology regulation, and dysfunction in disease. Curr Top Dev Biol 107:183–206.
Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G. 2002. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ 13:215–225.
Schneider CA, Rasband WS, Eliceiri KW. 2012. NIH Image to ImageJ: 25 years of image analysis. Nat Meth 9:671–675.
Sirkin DW. 1983. Critical defatting of frozen brain sections for optimal differentiation with the cresyl violet stain. Stain Technol 58:121–122.
Srinivas S, Watanabe T, Lin CS, William CM, Tanabe Y, Jessell TM, Costantini F. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1:4.
Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH. 2006. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442:929–933.
Urbán N, Guillemot F. 2014. Neurogenesis in the embryonic and adult brain: same regulators, different roles. Front Cell Neurosci 8:396.
Vanderluit JL, Ferguson KL, Nikoletopoulou V, Parker M, Ruzhynsky V, Alexson T, McNamara SM, Park DS, Rudnicki M, Slack RS. 2004. p107 regulates neural precursor cells in the mammalian brain. J Cell Biol 166:853–863.
Walkley CR, Orkin SH. 2006. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci USA 103:9057–9062.
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. 2001. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414:457–462.
Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. 2004. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 36:351–360.