Reference : Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/199074
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis.
English
GUIOT, Julien mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
Bondue, B. [> >]
HENKET, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
CORHAY, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
LOUIS, Renaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
23-May-2016
BMC pulmonary medicine
16
1
86
Yes (verified by ORBi)
International
1471-2466
1471-2466
England
[en] Idiopathic pulmonary fibrosis ; Insulin like growth factor binding proteins ; Insuline-like growth factors ; Pulmonary fibrosis
[en] BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to take part to the pathogenesis. We evaluated IGFs and IGFBPs in serum from patients with IPF and healthy subjects including 24 untreated IPF and 26 IPF receiving anti-fibrotic therapy and to compare them with healthy subjects. METHODS: Serum of 50 idiopathic pulmonary fibrosis and 55 healthy subjects (HS) were analysed by ELISA for IGFs and IGFBPs, TGF-beta and KL-6, the latter being tested as positive control in IPF. RESULTS: Serum levels of IGFBP-1 and IGFBP-2 and KL-6 were significantly higher in the IPF group than in the healthy subjects (p < 0.05, p < 0.001 and p < 0.0001 respectively) while the picture was inversed regarding IGFs. By contrast there was no significant difference between the groups with respect to TGF-beta. IGFBP-2 was significantly reduced in the patients with specific anti-fibrotic therapy pirfenidone and nintedanib compared to untreated patients (p < 0.05) but still significantly elevated in comparison to HS (p < 0.001). CONCLUSION: Serum IGFBP-1 and -2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. IGFBPs may be promising biomarkers in IPF.
http://hdl.handle.net/2268/199074
10.1186/s12890-016-0249-6
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877734/pdf/12890_2016_Article_249.pdf

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
GUIOT_Raised serum levels_BMC_ppediteur.pdfPublisher postprint688.19 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.