Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T -Relaxation properties.

amide proton transfer (APT); brain tumor; magnetization transfer ratio (MTRRex); relaxation-compensated APT (AREX); traditional asymmetry (MTRasym) analysis; water T1-relaxation correction

Abstract :

[en] PURPOSE: To provide insight into the effect of water T1 relaxation (T1wat ) on amide proton transfer (APT) contrast in tumors. Three different metrics of APT contrast-magnetization transfer ratio (MTRRex ), relaxation-compensated MTRRex (AREX), and traditional asymmetry (MTRasym )-were compared in normal and tumor tissues in a variety of intracranial tumors at 7 Tesla (T). METHODS: Six consented intracranial tumor patients were scanned using a low-power, three-dimensional (3D) APT imaging sequence. MTRRex and MTRasym were calculated in the region of 3 to 4 ppm. AREX was calculated by T1wat correction of MTRRex . Tumor tissue masks, which classify different tumor tissues, were drawn by an experienced neuroradiologist. ROI-averaged tumor tissue analysis was done for MTRRex , AREX, and MTRasym . RESULTS: MTRRex and MTRasym were slightly elevated in tumor-associated structures. Both metrics were positively correlated to T1wat . The correlation coefficient (R) was determined to be 0.88 (P < 0.05) and 0.92 (P << 0.05) for MTRRex and MTRasym , respectively. After T1wat correction (R = -0.21, P = 0.69), no difference between normal and tumor tissues was found for AREX. CONCLUSIONS: The strong correlation of MTRRex and MTRasym with T1wat and the absence thereof in AREX suggests that much of APT contrast in tumors for the low-power, 3D-acquisition scheme at 7 T originates from the inherent tissue water T1 -relaxation properties. Magn Reson Med, 2016. (c) 2016 Wiley Periodicals, Inc.

Disciplines :

Genetics & genetic processes

Author, co-author :

Khlebnikov, Vitaliy

Polders, Daniel

Hendrikse, Jeroen

Robe, Pierre ; Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Voormolen, Eduard H.

Luijten, Peter R.

Klomp, Dennis W. J.

Hoogduin, Hans

Language :

English

Title :

Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T -Relaxation properties.

Publication date :

2016

Journal title :

Magnetic Resonance in Medicine

ISSN :

0740-3194

eISSN :

1522-2594

Publisher :

John Wiley & Sons, Hoboken, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 24 June 2016

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