Reference : New Hosts of The Lassa Virus.
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/198854
New Hosts of The Lassa Virus.
English
Olayemi, Ayodeji [> >]
Cadar, Daniel [> >]
Magassouba, N. Faly [> >]
Obadare, Adeoba [> >]
Kourouma, Fode [> >]
Oyeyiola, Akinlabi [> >]
Fasogbon, Samuel [> >]
Igbokwe, Joseph [> >]
Rieger, Toni [> >]
Bockholt, Sabrina [> >]
Jerome, Hanna [> >]
Schmidt-Chanasit, Jonas [> >]
Garigliany, Mutien-Marie mailto [Université de Liège > Département de morphologie et pathologie (DMP) > Pathologie générale et autopsies >]
Lorenzen, Stephan [> >]
Igbahenah, Felix [> >]
Fichet, Jean-Nicolas [> >]
Ortsega, Daniel [> >]
Omilabu, Sunday [> >]
Gunther, Stephan [> >]
Fichet-Calvet, Elisabeth [> >]
2016
Scientific Reports
6
25280
Yes (verified by ORBi)
International
2045-2322
United Kingdom
[en] Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.
http://hdl.handle.net/2268/198854
10.1038/srep25280

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
srep25280.pdfPublisher postprint1.2 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.