[en] Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same chromosomal assignment. Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas. In addition, the testis and the seminoma showed specific expression of 2.3 kb transcript. Our results suggest that ZF genes on chromosome 19 may be implicated in the development and/or growth of seminomas.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Ogawa, Takehiko; Yokohama City University
Poncelet, Dominique A; Université de Liège - ULiège
Kinoshita, Yuzo; Yokohama City University
Noce, Toshiaki; Mitsubishi Kasei Institute of Life Sciences
Takeda, Mitsumasa; Yokohama City University
Kawamoto, Kanji; Yokohama City University
Udagawa, Koichi; Yokohama City University
Lecocq, Pierre J; Université de Liège - ULiège
Marine, Jean-Christophe; Université de Liège - ULiège
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Hosaka, Masahiko; Yokohama City University
Language :
English
Title :
Enhanced expression in seminoma of human zinc finger genes located on chromosome 19
Publication date :
1998
Journal title :
Cancer Genetics and Cytogenetics
ISSN :
0165-4608
eISSN :
1873-4456
Publisher :
Elsevier Science, New York, United States - New York
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