[en] Background
If “passenger lymphocyte syndrome” (PLS) is a well-recognized complication in ABO mismatched solid organ transplantation, the coexistence of this reaction with recipient’s alloimmunisation against multiple antigens expressed on the residual red blood cells in the graft is less common and unpredictable.
Methods
The receiver of an ABO minor mismatch liver graft from a cadaveric donor developed hemolytic anemia within 2 weeks after transplantation. The organ donor was of blood group O D+C+c+E+e+ K+k+ Le(a+b-) and the recipient, A1 D-C-c+E-e+ K-k+ Le(a-b-).
The donor and recipient were both tested for irregular antibodies. Elution was performed on the recipient’s red blood cells (RBCs).
Results
None of the recipient and donor had irregular alloantibodies at the time of transplantation. On day 10, anti-A antibodies was detected in the recipient’s serum and eluted from his RBCs. At the same time, the patient developed multiple alloantibodies: anti-D, anti-C, anti-E, anti-K and anti-Lea against the donor’s erythrocyte antigens.
Conclusion
Although serological analysis and hemolytic parameters confirmed the diagnosis of PLS which required transfusion support, no sign of graft damage due to recipient’s immune reaction was detected. This case illustrates the required follow-up of the recipient after transplantation.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
MONFORT, Mélanie ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
HONORE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
GOTHOT, André ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
GERARD, Christiane ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Language :
English
Title :
Simultaneous passenger lymphocyte syndrome and multiple alloimmunization against donor's blood group antigens after liver transplantation
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