Reference : Estradiol-induced neurogenesis in the female accessory olfactory bulb is required for...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/198059
Estradiol-induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor.
English
Brus, Maina [> >]
Trouillet, Anne-Charlotte [> >]
Hellier, Vincent mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Bakker, Julie mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2016
Journal of Neurochemistry
Blackwell Science
Yes (verified by ORBi)
International
0022-3042
1471-4159
Oxford
United Kingdom
[en] Aromatase-knockout mice ; cell proliferation ; cell survival ; functional integration ; olfactory stimulation
[en] Odors processed by the main and accessory olfactory bulbs (MOB, AOB) are important for sexual behavior. Interestingly, both structures continue to receive new neurons during adulthood. A role for olfactory neurogenesis in sexual behavior in female mice has recently been shown and gonadal hormones such as estradiol can modulate adult neurogenesis. Therefore, we wanted to determine the role of estradiol in learning the odors of sexual partners and in the adult neurogenesis of female aromatase-knockout mice (ArKO), unable to produce estradiol. Female WT and ArKO mice were exposed to male odors during 7 days and olfactory preferences, cell proliferation, cell survival and functional involvement of newborn neurons were analyzed, using BrdU injections, in combination with a marker of cell activation (Zif268) and neuronal fate (DCX, NeuN). Behavioral tasks indicated that both WT and ArKO females were able to discriminate between the odors of two different males, but ArKO mice failed to learn the familiar male odor. Proliferation of newborn cells was reduced in ArKO mice only in the dentate gyrus of the hippocampus. Olfactory exposure decreased cell survival in the AOB in WT females, suggesting a role for estradiol in a structure involved in sexual behavior. Finally, newborn neurons do not seem to be functionally involved in the AOB of ArKO mice compared with WT, when females were exposed to the odor of a familiar male, suggesting that estradiol-induced neurogenesis in the AOB is required for the learning of the male odor in female mice. This article is protected by copyright. All rights reserved.
http://hdl.handle.net/2268/198059
10.1111/jnc.13677
This article is protected by copyright. All rights reserved.

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