Reference : Sex Differences in White Matter Microstructure in the Human Brain Predominantly Refle...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/198056
Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure.
English
van Hemmen, J. [> >]
Saris, I. M. J. [> >]
Cohen-Kettenis, P. T. [> >]
Veltman, D. J. [> >]
Pouwels, P. J. W. [> >]
Bakker, Julie mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2017
Cerebral Cortex
Yes (verified by ORBi)
International
1047-3211
1460-2199
[en] CAIS ; DTI ; androgens ; sexual differentiation ; white matter
[en] Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extended WM regions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation of WM microstructure, although sex chromosome genes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role.
http://hdl.handle.net/2268/198056
10.1093/cercor/bhw156
(c) The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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