Unpublished conference/Abstract (Scientific congresses and symposiums)
Model-Based Decision Support Algorithm to Guide Fluid Resuscitation
Pironet, Antoine; Dauby, Pierre; MORIMONT, Philippe et al.
20164th IFAC International Conference on Intelligent Control and Automation Sciences (ICONS 2016)
 

Files


Full Text
Pironet2016Model2.pdf
Author preprint (13.23 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Fluid resuscitation is the first choice therapy for sepctic shock. However, fluid infusion only increases cardiac output in approximately 50 % of cases, while an excess of fluid can have harmful effects. Therefore, clinicians are looking for indices to predict the effect of fluid infusion on cardiac output, before giving fluid. In this work, a minimal mathematical model of the cardiovascular system is used, representing the heart, an artery and a vein. The nine model parameters, including total stressed blood volume, are identified from experimental data. The experimental data was recorded during three 500 ml fluid infusions on two pigs infected with endotoxin, to simulate septic shock. The total stressed blood volume parameter is negatively associated with the change in cardiac output after fluid infusion, as observed in previous studies. Subsequently, an algorithm is proposed to guide fluid resuscitation, based on the value of this parameter. The use of the algorithm results in 60 % less fluid being given with virtually no effect on cardiac output. The decision algorithm has the potential to be used in human clinical trials since the data required for parameter identification can be obtained in an intensive care unit.
Disciplines :
Cardiovascular & respiratory systems
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Pironet, Antoine ;  Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Dauby, Pierre  ;  Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
MORIMONT, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants
JANSSEN, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > Service des urgences
Chase, J. Geoffrey
Davidson, Shaun
Desaive, Thomas  ;  Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Model-Based Decision Support Algorithm to Guide Fluid Resuscitation
Publication date :
02 June 2016
Event name :
4th IFAC International Conference on Intelligent Control and Automation Sciences (ICONS 2016)
Event place :
Reims, France
Event date :
du 1 au 3 juin 2016
By request :
Yes
Audience :
International
Available on ORBi :
since 07 June 2016

Statistics


Number of views
68 (25 by ULiège)
Number of downloads
9 (9 by ULiège)

Bibliography


Similar publications



Contact ORBi