Evaluation of the efficacy and the safety of parenteral sulbactam/ampicillin folllowed by oral sultamicillin for paediatric infections.

The efficacy and the safety of parenteral sulbactam/ampicillin followed by oral sultamicillin* has been evaluated in 41 children aged between 0.5 and 15 years presenting with various infections.Overall clinical and bateriologial success was achieved in 92% of evaluable cases; 97% of 22 pathogens isolated in these patients were eradicated. Adverse reactions were pain at the intramuscular injections site (7%) which was minimized by concurrent injection of lidocaine. Gastro-intestinal disturbances with soft stools were common during oral sultamicillin therapy. Laboratory tests remained normal. Parental sulbactam/ampicillin followed by oral sultamicillin is useful therapy for the treatment of serious non-life-threatening paediatric infections.