Airways; dog; forced oscillation; respiratory impedance; obstruction to airways
Abstract :
[en] The resistance (Rrs) and reactance (Xrs) of the total respiratory system were determined at various frequencies in 14 healthy conscious beagle dogs. A pseudorandom noise pressure wave was produced at the nostrils of the animals by means of a loudspeaker adapted to the nose by a tightly fitting mask. A Fourier analysis of the pressure and flow signals yielded mean Rrs and Xrs, over 16 s, at frequencies from 2 to 26 Hz. The influence of the posture of the dog, the position of its head, the linearity of the respiratory system, the reproducibility of the method and the effects of upper and lower airway obstructions were studied. In sitting and standing healthy dogs with the head in the extended position, Rrs values increased progressively with frequency from 5.4 +/- 0.4 (SEM) cmH2O L-1s at 6 Hz up to 8.8 +/- 0.7 cmH2O L-1s at 26 Hz, the mean resonant frequency being 6.1 +/- 0.5 Hz. No significant differences were observed between measurements performed with the head in the normal or the extended position. In a recumbent posture, all Rrs values were increased but Rrs was still dependent on the frequency in the same way (7.1 +/- 0.7 cmH2O L-1s at 6Hz up to 10.0 +/- 0.5 cmH2O L-1s at 26 Hz). Tracheal compression also induced higher Rrs values without changes in the frequency dependence or in the resonant frequency. In anaesthetized dogs, airway obstruction was induced by inhalation of histamine (4 mg/ml for 5 min; the Rrs values tended to decrease with increasing frequency, and the resonant frequency was markedly increased
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Gustin, Pascal ; Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Landser, F. J.
Van de Woestijne, K. P.
Language :
English
Title :
Measurement of Total Respiratory Impedance in Dogs by the Forced Oscillation Technique
Art T., Lekeux P., Gustin P., Desmecht D., Amory H., Paiva M. (1989) Inertance of the respiratory system in ponies. Journal of Applied Physiology 67:534-540.
Bégin R., Cantin A., Landser F.J. (1988) Résistance respiratoire par oscillation forcée et VEMS pour évaluer la réactivité bronchique non spécifique. Revue des Maladies Respiratoires 5:389-392.
.
Clément J., Landser F.J., Van de Woestijne K.P. (1983) Total resistance and reactance in patients with respiratory complaints with and without airways obstruction. Chest 83:215-220.
Crosfill M.L., Widdicombe J.G. (1961) Physical characteristics of the chest and lungs and the work of breathing in different mammalian species. Journal of Physiology 158:1-14.
Dain D., Gold W.M. (1975) Mechanical properties of the lungs and experimental asthma in conscious allergic dogs. Journal of Applied Physiology 38:96-100.
Duivermann E.J., Neijens H.J., Vander Snee-Van Smaalen M., Kerrebijn K.J. (1986) Comparison of forced oscillometry and forced expirations for measuring dose-related responses to inhaled metacholine in asthmatic children. Bulletin Européen Physiopathologie Respiratoire 22:433-436.
Frank N.R., Mead J., Whittenberger J.L. (1971) Comparative sensitivity of four techniques for measuring changes in respiratory flow resistance in man. Journal of Applied Physiology 31:934-938.
Fredberg J.F., Ingram R.H., Castile R.G., Glass G.M., Drazen J.M. (1985) Nonhomogeneity of lung response to inhaled histamine assessed with alveolar capsules. Journal of Applied Physiology 58:1914-1922.
Fullton J.M., Hayes D.M., Pimmel R.L. (1982) Pulmonary impedance in dogs measured by forced random noise with a retrograde catheter. Journal of Applied Physiology 52:725-733.
Gillespie D.J., Hyatt R.E. (1974) Respiratory mechanics in the unanesthetized dog. Journal of Applied Physiology 36:98-102.
Grimby G., Takishima T., Graham W., Macklem P., Mead J. (1968) Frequency dependence of flow resistance in patients with obstructive lung disease. The Journal of Clinical Investigation 47:1455-1465.
Gustin P., Dhem A.R., Lomba F., Lekeux P., Van de Woestijne K.P., Landser F.J. (1988) Measurement of total respiratory impedance in calves by forced oscillation technique. Journal of Applied Physiology 64:1786-1791.
Gustin P., Dhem A.R., Lekeux P., Lomba F., Landser F.J., Van de Woestijne K.P. (1988) Investigation of the effects of histamine inhalation on the tracheobronchial tree of calves by the forced oscillation technique. Journal of Veterinary Pharmacology and Therapeutics 11:374-380.
Harf A., Decramer M., Zin A., Milic-Emili J., Chang K. (1985) Respiratory resistance in dogs by the single-breath and forced oscillation methods. Journal of Applied Physiology 59:262-265.
Hull W.E., Long E.C. (1961) Respiratory impedance and volume flow at high frequency in dogs. Journal of Applied Physiology 16:439-443.
Jackson A.C., Watson J.W., Kotlikoff M.I. (1984) Respiratory system, lung and chest wall impedances in anesthetized dogs. Journal of Applied Physiology 57:34-39.
Kappos A.D., Rodarte J.R., Lai-Fook S.J. (1981) Frequency dependence and partitioning of respiratory impedance in dogs. Journal of Applied Physiology 51:621-628.
Landser F.J., Nagels J., Demedts M., Billiet L., Van de Woestijne K.P. (1976) A new method to determine frequency characteristics of the respiratory system. Journal of Applied Physiology 41:101-106.
Mead J. (1969) Contribution of compliance of airways to frequency dependent behaviour of lungs. Journal of Applied Physiology 26:670-673.
Michels A., Loveniers M., Van de Woestijne K.P. (1991) Influence of head position on the impedance of the respiratory system. European Respiratory Reviews 1:229-231.
Michaelson E.D., Grassman E.D., Peters W.R. (1975) Pulmonary mechanics by spectral analysis of forced random noise. Journal of Clinical Investigation 56:1210-1230.
Muggenburg B.A., Mauderly J.L. (1974) Cardiopulmonary function of awake, sedated, and anesthetized beagle dogs. Journal of Applied Physiology 37:152-157.
Nagels J., Landser F.J., Van der Linden L., Clément J., Van de Woestijne K.P. (1980) Mechanical properties of lung and chest wall during spontaneous breathing. Journal of Applied Physiology 49:408-415.
Pickrell J.A., Dubin S.E., Elliott J.C. (1971) Normal respiratory parameters of unanesthetized beagle dogs. Laboratory Animal Science 21:677-679.
Pimmel R.L., Fullton J.M., Ginsberg J.F., Hazucha M.J., Haak E.D., McDonnell W.F., Bromberg P.A. (1981) Correlation of airway resistance with forced random noise resistance parameters. Journal of Applied Physiology 51:33-39.
Van Brabandt H., Cauberghs M., Verbeken E., Moerman P., Lauweryns J.M., Van de Woestijne K.P. (1983) Partitioning of pulmonary impedance in excised human and canine lungs. Journal of Applied Physiology 55:1733-1742.