Article (Scientific journals)
Managing children with chronic myeloid leukaemia (CML) Recommendations for the management of CML in children and young people up to the age of 18 years
de la Fuente, Josu; Baruchel, André; Biondi, Andrea et al.
2014In British Journal of Haematology, 167, p. 33-47
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Keywords :
chronic myeloid leukaemia; children; tyrosine kinase inhibitor; stem cell transplantation; BCR-ABL1
Abstract :
[en] Chronic myeloid leukaemia in children and young people is a relatively rare form of leukaemia that shows increased incidence with age and some evidence suggests that the molecular basis differs from that in adults. Significant advances in targeted therapy with the development and use in children of tyrosine kinase inhibitors and the ability to monitor and understand the prognostic significance of minimal residual disease by standardized molecular techniques has shifted the management of this condition from bone marrow transplantation as the main therapeutic modality to individualized treatment for each patient based on achieving specific milestones. The physiological changes occurring during childhood, particularly those affecting growth and development and the long-term use of treatment, pose specific challenges in this age group, which we are only beginning to understand.
Disciplines :
Pediatrics
Author, co-author :
de la Fuente, Josu
Baruchel, André
Biondi, Andrea
de Bont, Eveline
DRESSE, Marie-Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Service de pédiatrie (CHR)
Suttorp, Meinolf
Millot, Frédéric
Language :
English
Title :
Managing children with chronic myeloid leukaemia (CML) Recommendations for the management of CML in children and young people up to the age of 18 years
Publication date :
2014
Journal title :
British Journal of Haematology
ISSN :
0007-1048
eISSN :
1365-2141
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
167
Pages :
33-47
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 May 2016

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