Reference : Ozone-Induced Stimulation of Pulmonary Sympathetic Fibers: A Protective Mechanism aga...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Life sciences : Veterinary medicine & animal health
Ozone-Induced Stimulation of Pulmonary Sympathetic Fibers: A Protective Mechanism against Edema
Delaunois, Annie mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Segura, P. [> > > >]
Dessy, Cécile mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire) >]
Ansay, Michel mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire) >]
Montano, L. M. [> > > >]
Vargas, M. H. [> > > >]
Gustin, Pascal mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
Toxicology and Applied Pharmacology
Academic Press
Yes (verified by ORBi)
New York
[en] Time Factors ; Substance P/toxicity ; Rabbits ; Pulmonary Wedge Pressure/drug effects ; Pulmonary Edema/chemically induced/prevention & control ; Ozone/toxicity ; Neuropeptide Y/antagonists & inhibitors ; Nerve Fibers/drug effects/pathology ; Microscopy, Electron ; Male ; Lung/blood supply/drug effects/innervation ; Guanethidine/pharmacology ; Female ; Dose-Response Relationship, Drug ; Catecholamines/blood/urine ; Capillary Permeability/drug effects ; Animals ; Adrenergic beta-Antagonists/pharmacology ; Adrenergic alpha-Antagonists/pharmacology ; Adrenergic Agents/pharmacology ; Acetylcholine/toxicity ; Ozone ; respiratory tract ; Edema
[en] Tropospheric ozone exerts well-described toxic effects on the respiratory tract. Less documented, by contrast, is the ability of ozone to induce protective mechanisms against agents that are toxic to the lungs. In particular, interactions between ozone and the sympathetic nervous system have never been considered. Using a model of permeability edema in isolated perfused rabbit lungs, we report here that, immediately after exposure of rabbits to 0.4 ppm ozone for 4 hr, the pulmonary microvascular responses to acetylcholine and substance P are completely blocked. Several lines of evidence, including partial inhibition of the ozone-induced protective effect by several drugs (alpha2- and beta-adrenergic antagonists, neuropeptide Y antagonist, guanethidine), measured levels of released catecholamines in blood and urine and the in vitro response of isolated lungs exposed to 0.4 ppm ozone all seem to suggest that ozone can stimulate pulmonary adrenergic fibers and induce the local release of catecholamines and neuropeptide Y, this resulting in transient protection against pulmonary edema. We also showed that, 48 hr after the exposure, ozone increased the baseline microvascular permeability and the response to low concentrations of acetylcholine
Fonds de la Recherche Scientifique (Communauté française de Belgique) - FNRS; the European Communities (grant CI1*CT93-0032).
Researchers ; Professionals ; Students
Copyright 1997 Academic Press.

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