[en] Lameness due to stifle and especially meniscal lesions is frequent in equine species.
In humans, mechanoreceptors involved in proprioceptive function are well
studied. Given the high incidence of meniscal injuries in horses, and the lack
of information concerning them in equine menisci, our objective was to study
these corpuscles in six healthy anterior horns of the equine medial meniscus,
which is the most common localisation reported for equine meniscal injuries.
Immunohistochemical stainings were performed using antibodies against high
molecular weight neurofilaments and glial fibrillary acidic proteins. From a
purely fundamental point of view, our work highlights for the first time the
presence of Ruffini, Pacini and Golgi corpuscles in equine meniscus. They were
found, isolated or in clusters and always located at the vicinity of blood vessels,
at the level of the anterior horn of the equine medial meniscus. This morphological
approach could serve as a basis for clinical studies, to evaluate the
impact of these corpuscles on the poor sportive prognosis in equine meniscal
tears.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Nemery, Elodie ; Université de Liège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques
Gabriel, Annick ; Université de Liège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques
Grulke, Sigrid ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
Piret, Joëlle ; Université de Liège > Département de morphologie et pathologie (DMP) > Département de morphologie et pathologie (DMP)
Toppets, Vinciane ; Université de Liège > Scientifiques attachés au Doyen (F MV)
Antoine, Nadine ; Université de Liège > Département de morphologie et pathologie (DMP) > Histologie
Language :
English
Title :
Mechanoreceptors in the anterior horn of the equine medial meniscus: an immunohistochemical approach
Akgun, U., B. Kocaoglu, E. K. Orhan, M. B. Baslo, and M. Karahan, 2008: Possible reflex pathway between medial meniscus and semimembranosus muscle: an experimental study in rabbits. Knee Surg. Sports Traumatol. Arthrosc. 16, 809-814.
Assimakopoulos, A. P., P. G. Katonis, M. V. Agapitos, and E. I. Exarchou, 1992: The innervation of the human meniscus. Clin. Orthop. Relat. Res. 275, 232-236.
Aydog, S. T., P. Korkusuz, M. N. Doral, O. Tetik, and H. A. Demirel, 2006: Decrease in the numbers of mechanoreceptors in rabbit ACL: the effects of ageing. Knee Surg. Sports Traumatol. Arthrosc. 14, 325-329.
Bali, K., M. S. Dhillon, R. K. Vasistha, N. Kakkar, R. Chana, and S. Prabhakar, 2012: Efficacy of immunohistological methods in detecting functionally viable mechanoreceptors in the remnant stumps of injured anterior cruciate ligaments and its clinical importance. Knee Surg. Sports Traumatol. Arthrosc. 20, 75-80.
Banks, R. W., M. Hulliger, H. H. Saed, and M. J. Stacey, 2009: A comparative analysis of the encapsulated end-organs of mammalian skeletal muscles and of their sensory nerve endings. J. Anat. 214, 859-887.
Barker, D., 1974: Handbook of Sensory Physiology III/2 Muscle Receptors. Berlin: Springer-Verlag.
Cavalcante, M. L., C. J. Rodrigues, and R. Jr Mattar, 2004: Mechanoreceptors and nerve endings of the triangular fibrocartilage in the human wrist. J. Hand Surg. Am. 29, 432-438.
Chevrier, A., M. Nelea, M. B. Hurtig, C. D. Hoemann, and M. D. Buschmann, 2009: Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair. J. Orthop. Res. 27, 1197-1203.
Cohen, J. M., D. W. Richardson, A. L. McKnight, M. W. Ross, and R. C. Boston, 2009: Long-term outcome in 44 horses with stifle lameness after arthroscopic exploration and debridement. Vet. Surg. 38, 543-551.
De Busscher, V., D. Verwilghen, G. Bolen, D. Serteyn, and V. Busoni, 2006: Meniscal damage diagnosed by ultrasonography in horses: a retrospective study of 74 femorotibial joint ultrasonographic examinations (2000-2005). J. Equine. Vet. Sci. 26, 453-461.
Delgado-Baeza, E., V. Utrilla-Mainz, J. Contreras-Porta, I. Santos-Alvarez, and A. Martos-Rodríguez, 1999: Mechanoreceptors in collateral knee ligaments: an animal experiment. Int. Orthop. 23, 168-171.
Dhillon, M. S., K. Bali, and R. K. Vasistha, 2010: Immunohistological evaluation of proprioceptive potential of the residual stump of injured anterior cruciate ligaments (ACL). Int. Orthop. 34, 737-741.
Ferris, D. J., D. D. Frisbie, J. D. Kisiday, C. W. McIlwraith, B. A. Hague, M. D. Major, R. K. Schneider, C. J. Zubrod, C. E. Kawcak, and L. R. Goodrich, 2014: Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury. Vet. Surg. 43, 255-265.
Fowlie, J., S. Arnoczky, M. Lavagnino, T. Maerz, and J. Stick, 2011a: Resection of Grade III cranial horn tears of the equine medial meniscus alter the contact forces on medial tibial condyle at full extension: an in-vitro cadaveric study. Vet. Surg. 40, 957-965.
Fowlie, J. G., S. P. Arnoczky, J. A. Stick, and A. P. Pease, 2011b: Meniscal translocation and deformation throughout the range of motion of the equine stifle joint: an in vitro cadaveric study. Equine Vet. J. 43, 259-264.
Fowlie, J. G., S. P. Arnoczky, M. Lavagnino, and J. A. Stick, 2012: Stifle extension results in differential tensile forces developing between abaxial and axial components of the cranial meniscotibial ligament of the equine medial meniscus: a mechanistic explanation for meniscal tear patterns. Equine Vet. J. 44, 554-558.
Freeman, M. A. R., and B. Wyke, 1967: The innervation of the knee joint. An anatomical and histological study in the cat. J. Anat. 101, 505-532.
Gray, J. C., 1999: Neural and vascular anatomy of the menisci of the human knee. J. Orthop. Sports Phys. Ther. 29, 23-30.
Halata, Z., 1977: The ultrastructure of the sensory nerve endings in the articular capsule of the knee joint of the domestic cat (Ruffini corpuscles and Pacinian corpuscles). J. Anat. 124, 717-729.
Halata, Z., and J. Haus, 1989: The ultrastructure of sensory nerve endings in human anterior cruciate ligament. Anat. Embryol. 179, 415-421.
Halata, Z., T. Rettig, and W. Schulze, 1985: The ultrastructure of sensory nerve endings in the human knee joint capsule. Anat. Embryol. 172, 265-275.
Heijink, A., A. H. Gomoll, H. Madry, M. Drobnic, G. Filardo, J. Espregueira-Mendes, and C. N. Van Dijk, 2012: Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surg. Sports Traumatol. Arthrosc. 20, 423-435.
Hogervorst, T., and R. A. Brand, 1998: Current concepts review: mechanoreceptors in joint function. J. Bone Joint Surg. 80-A, 1365-1378.
Karahan, M., B. Kocaoglu, C. Cabukoglu, U. Akgun, and R. Nuran, 2010: Effect of partial medial meniscectomy on the proprioceptive function of the knee. Arch. Orthop. Trauma Surg. 130, 427-431.
Kim, S. H., C. H. Chun, K. C. Chun, H. J. Jo, and K. M. Kim, 2012: Histological assessment of mechanoreceptors in Achilles allografts after anterior cruciate ligament reconstruction. Am. J. Sports Med. 40, 2061-2065.
Lee, B. I., K. D. Min, H. S. Choi, S. W. Kwon, D. I. Chun, E. S. Yun, D. W. Lee, S. Y. Jin, and J. H. Yoo, 2009: Immunohistochemical study of mechanoreceptors in the tibial remnant of the ruptured anterior cruciate ligament in human knees. Knee Surg. Sports Traumatol. Arthrosc. 17, 1095-1101.
Mine, T., M. Kimura, A. Sakka, and S. Kawai S, 2000: Innervation of nociceptors in the menisci of the knee joint: an immunohistochemical study. Arch. Orthop. Trauma Surg. 120, 201-204.
Møller, A. R., 2002: Sensory Systems: Anatomy, Physiology and Pathophysiology. Burlington: Elsevier Science.
Moon, M. S., and Y. S. Kim, 1997: Collagen fibres and mechanoreceptors in regenerated menisci of rabbits. Int. Orthop. 21, 239-242.
O'Connor, B. L., 1984: The mechanoreceptor innervation of the posterior attachments of the lateral meniscus of the dog knee joint. J. Anat. 138, 15-26.
O'Connor, B. L., and J. S. McConnaughey, 1978: The structure and innervation of cat knee menisci, and their relation to a "sensory hypothesis" of meniscal function. Am. J. Anat 153, 431-442.
Olivier, A., J. P. Nurton, and A. J. Guthrie, 1997: An epizoological study of wastage in Thoroughbred racehorses in Gauteng, South Africa. J. S. Afr. Vet. Assoc. 68, 125-129.
Proske, U., and S. C. Gandevia, 2012: The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force. Physiol. Rev. 92, 1651-1697.
Raunest, J., M. Sager, and E. Bürgener, 1998: Proprioception of the cruciate ligaments: receptor mapping in an animal model. Arch. Orthop. Trauma Surg. 118, 159-163.
Rein, S., E. Hagert, U. Hanisch, S. Lwowski, A. Fieguth, and H. Zwipp, 2013a: Immunohistochemical analysis of sensory nerve endings in ankle ligaments: a cadaver study. Cells Tissues Organs. 197, 64-76.
Rein, S., U. Hanisch, H. Zwipp, A. Fieguth, S. Lwowski, and E. Hagert, 2013b: Comparative analysis of inter- and intraligamentous distribution of sensory nerve endings in ankle ligaments: a cadaver study. Foot Ankle Int. 34, 1017-1024.
Saygi, B., Y. Yildirim, N. Berker, D. Ofluoglu, E. Karadag-Saygi, and M. Karahan, 2005: Evaluation of the neurosensory function of the medial meniscus in humans. Arthroscopy. 21, 1468-1472.
Stashak, T. S., 2002: Adams' Lameness in Horses, 5th edn. Baltimore: Lippincott Williams & Wilkins.
Walmsley, J. P., 2005: Diagnosis and treatment of ligamentous and meniscal injuries in the equine stifle. Vet. Clin. North Am. Equine Pract. 21, 651-672.
Walmsley, J. P., T. J. Phillips, and H. G. G. Townsend, 2003: Meniscal tears in horses: an evaluation of clinical signs and arthroscopic treatment of 80 cases. Equine Vet. J. 35, 402-406.