La sclérostine: un nouveau biomarqueur d'intérêt en néprhologie

[en] Sclerostin is an osteocyte-specific glycoprotein secreted by the osteocyte and involved in the regulation of bone mass. High sclerostin levels are associated with osteoporosis, whereas low sclerostin levels are correlated with higher bone mineral density. It seems interesting to investigate a potential association between sclerostin levels and vascular calcifications since sclerostin is considered as a potent inhibitor of bone formation. In chronic kidney disease, serum sclerostin levels rise as renal function declines. Preliminary studies show a positive association between serum sclerostin and vascular calcification, but the link between sclerostin and survival of patients remains unclear in the absence of large-scale studies.

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

Pelletier, Solenne

Jean, Guillaume

Fouque, Denis

CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique

DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie

Souberbielle, Jean-Claude

Zaoui, Ph.

Cristol, J.P.

Urena-Torres, P.

Boutten, A

More authors (14 more)

Language :

French

Title :

La sclérostine: un nouveau biomarqueur d'intérêt en néprhologie

Alternative titles :

[en] Sclerostin: a new biomarker of interest in nephrology

Publication date :

May 2015

Journal title :

Annales de Biologie Clinique

ISSN :

0003-3898

eISSN :

1950-6112

Publisher :

John Libbey Eurotext, Montrouge, France

Volume :

Issue :

Pages :

305-13

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Groupe de travail mixte SFBC/SN : « Biomarqueurs de calcifications vasculaires au cours de l’Insuffisance rénale chronique » Membres du groupe : J. Arnaud et Ph. Zaoui, CHU Grenoble ; M.C. Carlier, M. Laville et D. Fouque CHU Lyon ; E. Cavalier et P. Delanaye, CHU Sart- Tilman Liège ; J.P. Cristol et A.S. Bargnoux,CHUMontpellier ; S. Kamel et Z. Massy, Université de Picardie ; D. Prié, P. Urena-Torres et J.C. Souberbielle, Inserm/Université U 845 ; A. Boutten, CHU Paris-Nord ; A. Guérin, CH de Manhes ; T. Hannedouche, CHU Strasbourg, Ph. Brunet CHU Marseille ; G. Jean, Nephrocare Tassin-Charcot ; M.H. Lafage-Proust CHU St Etienne ; G. London, Inserm U970 ; L. Mercadal, Pitié Salpêtrière Paris ; L. Pieroni, CH Avignon doi:10.1684/abc.2015.1049

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since 17 May 2016

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