bone; vascular calcification; sclerostin; sclérostine; calcification vasculaire; os
Abstract :
[en] Sclerostin is an osteocyte-specific glycoprotein secreted by the osteocyte and involved in the regulation of bone mass. High sclerostin levels are associated with osteoporosis, whereas low sclerostin levels are correlated with higher bone mineral density. It seems interesting to investigate a potential association between sclerostin levels and vascular calcifications since sclerostin is considered as a potent inhibitor of bone formation. In chronic kidney disease, serum sclerostin levels rise as renal function declines. Preliminary studies show a positive association between serum sclerostin and vascular calcification, but the link between sclerostin and survival of patients remains unclear in the absence of large-scale studies.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Pelletier, Solenne
Jean, Guillaume
Fouque, Denis
CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique
DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
La sclérostine: un nouveau biomarqueur d'intérêt en néprhologie
Alternative titles :
[en] Sclerostin: a new biomarker of interest in nephrology
Publication date :
May 2015
Journal title :
Annales de Biologie Clinique
ISSN :
0003-3898
eISSN :
1950-6112
Publisher :
John Libbey Eurotext, Montrouge, France
Volume :
73
Issue :
3
Pages :
305-13
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Groupe de travail mixte SFBC/SN : « Biomarqueurs de calcifications vasculaires au cours de l’Insuffisance
rénale chronique » Membres du groupe : J. Arnaud et Ph. Zaoui, CHU Grenoble ; M.C. Carlier, M. Laville et D. Fouque CHU Lyon ; E. Cavalier et P. Delanaye, CHU Sart- Tilman Liège ; J.P. Cristol et A.S. Bargnoux,CHUMontpellier ; S. Kamel et Z. Massy, Université de Picardie ; D. Prié, P. Urena-Torres et J.C. Souberbielle, Inserm/Université U 845 ; A. Boutten, CHU Paris-Nord ; A. Guérin, CH de Manhes ; T. Hannedouche, CHU Strasbourg, Ph. Brunet CHU Marseille ; G. Jean, Nephrocare Tassin-Charcot ; M.H. Lafage-Proust CHU St Etienne ; G. London, Inserm U970 ; L. Mercadal, Pitié Salpêtrière Paris ; L. Pieroni, CH Avignon
doi:10.1684/abc.2015.1049
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