Implant osseointegration; Implant anchorage; Bone remodeling; Metal artifacts; In vivo micro-computed tomography
Abstract :
[en] The mechanical integrity of the bone-implant system is maintained by the process of bone remodeling. Specifically, the interplay between bone resorption and bone formation is of paramount importance to fully understand the net changes in bone structure occurring in the pen-implant bone, which are eventually responsible for the mechanical stability of the bone-implant system. Using time-lapsed in vivo micro-computed tomography combined with new composite material implants, we were able to characterize the spatio-temporal changes of bone architecture and bone remodeling following implantation in living mice. After insertion, implant stability was attained by a quick and substantial thickening of the cortical shell which counteracted the observed loss of trabecular bone, probably due to the disruption of the trabecular network. Within the trabecular compartment, the rate of bone formation close to the implant was transiently higher than far from the implant mainly due to an increased mineral apposition rate which indicated a higher osteoblastic activity. Conversely, in cortical bone, the higher rate of bone formation close to the implant compared to far away was mostly related to the recruitment of new osteoblasts as indicated by a prevailing mineralizing surface. The behavior of bone resorption also showed dissimilarities between trabecular and cortical bone. In the former, the rate of bone resorption was higher in the pen-implant region and remained elevated during the entire monitoring period. In the latter, bone resorption rate had a bigger value away from the implant and decreased with time. Our approach may help to tune the development of smart implants that can attain a better long-term stability by a local and targeted manipulation of the remodeling process within the cortical and the trabecular compartments and, particularly, in bone of poor health. (C) 2015 Elsevier Inc. All rights reserved.
Ruffoni, Davide ; Université de Liège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
Title :
In vivo monitoring of bone architecture and remodeling after implant insertion: The different responses of cortical and trabecular bone
Publication date :
2015
Journal title :
BONE
ISSN :
8756-3282
eISSN :
1873-2763
Publisher :
Elsevier Science Inc, New York, United States - New York
Volume :
81
Pages :
468-477
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
CSC - Chinese Scholarship Council
Funding text :
IOF-SERVIER Young Investigator Research Grant; ECTS Postdoctoral Fellowship
Commentary :
The authors would like to thank Harry van Lenthe from KU Leuven and Romano Matthys from RISystem for fruitful discussions. ZL acknowledges support of the Chinese Scholarship Council and DR of the IOF-SERVIER Young Investigator Research Grant as well as of the ECTS Postdoctoral Fellowship.
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