Reference : Core cross-linked micelles of polyphosphoester containing amphiphilic block copolymer...
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/195601
Core cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
English
Ergül, Zeynep [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Vanslambrouck, Stéphanie [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Cajot, Sébastien [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Thiry, Justine [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Debuigne, Antoine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Lecomte, Philippe mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Jérôme, Christine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Riva, Raphaël [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
2016
RSC Advances
Royal Society of Chemistry Publishing
6
48
42081-42088
Yes (verified by ORBi)
International
2046-2069
Cambridge
United Kingdom
[en] biomaterial ; nanomedicine
[en] Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the stability of the micelles at high dilution by crosslinking the hydrophobic polyphosphoester micellar core. Typically, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. This strategy avoids the use of any organometallic compounds in order to facilitate the purification and meet the stringent requirements of biomedical applications. After self-assembly into water, the micelles were cross-linked by simple UV irradiation. These cross-linked micelles have then been loaded by doxorubicin to evaluate their potential as drug nanocarriers and monitor the impact of crosslinking on the release profile.
Center for Education and Research on Macromolecules (CERM)
The International Doctoral School Nanofar ; The Walloon Region and the European Community in the frame of the Interreg Program BioMIMedics ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/195601
10.1039/C6RA07422G

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