[en] Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the stability of the micelles at high dilution by crosslinking the hydrophobic polyphosphoester micellar core. Typically, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. This strategy avoids the use of any organometallic compounds in order to facilitate the purification and meet the stringent requirements of biomedical applications. After self-assembly into water, the micelles were cross-linked by simple UV irradiation. These cross-linked micelles have then been loaded by doxorubicin to evaluate their potential as drug nanocarriers and monitor the impact of crosslinking on the release profile.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Ergül, Zeynep ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Vanslambrouck, Stéphanie ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Cajot, Sébastien; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Thiry, Justine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Debuigne, Antoine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lecomte, Philippe ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Riva, Raphaël ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Core cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
Publication date :
2016
Journal title :
RSC Advances
eISSN :
2046-2069
Publisher :
Royal Society of Chemistry Publishing, Cambridge, United Kingdom
Volume :
6
Issue :
48
Pages :
42081-42088
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The International Doctoral School Nanofar The Walloon Region and the European Community in the frame of the Interreg Program BioMIMedics F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique