[en] OBJECTIVE: To assess the progression of plasma D-dimer concentrations and coagulation status in horses with different types of colic. DESIGN: Prospective clinical observational study performed between March 2004 and September 2008. SETTING: Veterinary university teaching hospital. ANIMALS: Horses admitted and treated for colic and hospitalized for >48 hours were considered. Animals were classified by diagnosis into medical obstructive conditions (MO), surgical obstructive conditions (SO), inflammatory conditions, and ischemic lesions (IS). INTERVENTIONS: Three blood samples were obtained from each horse (admission, at 24-48 h [or after surgery] and upon discharge). For each sample, plasma D-dimer concentration, prothrombin time, activated partial thromboplastin time, antithrombin activity, and the presence of subclinical disseminated intravascular coagulation were determined. MEASUREMENTS AND MAIN RESULTS: When median plasma D-dimer concentration values at admission and after 24-48 hours were compared, they were different but stable in horses with MO (1.29-1.95 nmol/L) and inflammatory conditions (5.70-6.69 nmol/L). However, 10-fold and 5-fold increases were observed, respectively, in SO (2.08 to 16.38 nmol/L) and IS (3.08 to 15.91 nmol/L) in the postoperative period. By 24-48 hours, the percentage of horses with coagulopathy increased in most groups (MO, 43 to 58%; SO, 50 to 96%, IS, 53 to 90%). By the time of discharge, 87% of horses with SO problems and 89% of horses with IS still had some form of coagulopathy documented. CONCLUSIONS: Throughout hospitalization, horses with MO problems had less severe coagulopathy and lower plasmatic D-dimer concentrations compared to other groups of horses. On admission, most horses with inflammatory conditions presented with coagulopathy. At 24-48 hours of hospitalization and following surgery, the hemostatic profile can differ markedly when compared to admission values.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Cesarini Latorre, Carlota ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Monreal, Luis
Armengou, Lara
Delgado, M. Angeles
Rios, Jose
Jose-Cunilleras, Eduard
Language :
English
Title :
Progression of plasma D-dimer concentration and coagulopathies during hospitalization in horses with colic.
Publication date :
2014
Journal title :
Journal of Veterinary Emergency and Critical Care
ISSN :
1479-3261
eISSN :
1476-4431
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
24
Issue :
6
Pages :
672-80
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) Veterinary Emergency and Critical Care Society 2014.
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