[en] Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
Research Center/Unit :
MIT
Disciplines :
Chemistry
Author, co-author :
Adamo, Andrea; Massachusetts Institute of Technology - MIT > Chemical Engineering
Beingessner, Rachel L.; Massachusetts Institute of Technology - MIT > Chemistry
Behnam, Mohsen; Massachusetts Institute of Technology - MIT > Chemical Engineering
Chen, Jie; Massachusetts Institute of Technology - MIT > Chemical Engineering
Jamison, Timothy F.; Massachusetts Institute of Technology - MIT > Chemistry
Jensen, Klavs F.; Massachusetts Institute of Technology - MIT > Chemical Engineering
Monbaliu, Jean-Christophe ; Université de Liège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis - CiTOS
Myerson, Allan S.; Massachusetts Institute of Technology - MIT > Chemical Engineering
Revalor, Eve M.; Massachusetts Institute of Technology - MIT > Chemical Engineering
Snead, David R.; Massachusetts Institute of Technology - MIT > Chemistry
Stelzer, Torsten; Massachusetts Institute of Technology - MIT > Chemical Engineering
Weeranoppanant, Nopphon; Massachusetts Institute of Technology - MIT > Chemical Engineering
Wong, Shin Yee; Massachusetts Institute of Technology - MIT > Chemical Engineering
Zhang, Ping; Massachusetts Institute of Technology - MIT > Chemistry
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