Reference : On-demand continuous flow production of pharmaceuticals in a compact, reconfigurable ...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/195182
On-demand continuous flow production of pharmaceuticals in a compact, reconfigurable system
English
Adamo, Andrea [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Beingessner, Rachel L. [Massachusetts Institute of Technology - MIT > Chemistry > > >]
Behnam, Mohsen [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Chen, Jie [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Jamison, Timothy F. [Massachusetts Institute of Technology - MIT > Chemistry > > >]
Jensen, Klavs F. [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Monbaliu, Jean-Christophe mailto [Université de Liège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis - CiTOS > >]
Myerson, Allan S. [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Revalor, Eve M. [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Snead, David R. [Massachusetts Institute of Technology - MIT > Chemistry > > >]
Stelzer, Torsten [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Weeranoppanant, Nopphon [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Wong, Shin Yee [Massachusetts Institute of Technology - MIT > Chemical Engineering > > >]
Zhang, Ping [Massachusetts Institute of Technology - MIT > Chemistry > > >]
2016
Science
American Association for the Advancement of Science
352
61-67
Yes (verified by ORBi)
International
0036-8075
1095-9203
Washington
DC
[en] Continuous-flow manufacturing ; On-demand production ; Microfluidics
[en] Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
MIT
DARPA
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/195182
10.1126/science.aaf1337
http://science.sciencemag.org/content/352/6281/61
http://reflexions.ulg.ac.be/en/DrugFactory

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