Article (Scientific journals)
Breast cancer in a male to female transsexual patient with a BRCA2 mutation
CORMAN, Vinciane; Potorac, Iulia; Manto, Florence et al.
2016In Endocrine-Related Cancer, 23 (5), p. 391-397
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Abstract :
[en] Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g., BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in male breast cancer pathophysiology. Male-to-female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female hormonal environment and induce the cross-sex secondary characteristics. In certain situations, the change in the hormonal milieu can be disadvantageous and favor the development of hormonedependent pathologies, such as cancer. We report a case of a MtF transgender patient who developed breast cancer after 7 years of cross-sex hormonal therapy. The patient was found to be BRCA2 positive, and suffered recurrent disease. The patient was unaware of being a member of an established BRCA2 mutation-positive kindred. This represents the first case of a BRCA2 mutation predisposing to breast cancer in a MtF transgender patient.
Disciplines :
Oncology
Author, co-author :
CORMAN, Vinciane  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
Potorac, Iulia  ;  Université de Liège - ULiège > Doct. sc. médicales (Bologne)
Manto, Florence ;  Université de Liège - ULiège > Master méd. (ex 4e master en 4 ans)
Dassy, Sarah
SEGERS, Karin ;  Centre Hospitalier Universitaire de Liège - CHU > Service de génétique
THIRY, Albert ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'anatomie et cytologie pathologiques
Bours, Vincent ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Daly, Adrian  ;  Université de Liège > Département des sciences cliniques > Endocrinologie
BECKERS, Albert ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
 These authors have contributed equally to this work.
Language :
English
Title :
Breast cancer in a male to female transsexual patient with a BRCA2 mutation
Publication date :
2016
Journal title :
Endocrine-Related Cancer
ISSN :
1351-0088
eISSN :
1479-6821
Publisher :
Society for Endocrinology, Bristol, United Kingdom
Volume :
23
Issue :
5
Pages :
391-397
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2016

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