Article (Scientific journals)
Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH cells.
Rotondi, Sandra; Modarelli, Alessio; Oliva, Maria-Antonietta et al.
2016In Molecular and Cellular Endocrinology
Peer Reviewed verified by ORBi
 

Files


Full Text
MolecularCellularEndo-Rotondi2016.pdf
Publisher postprint (2.88 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Acromegaly; Aryl hydrocarbon receptor interacting protein (AIP); Fenofibrate; GH(3) cells; Peroxisome proliferator-activated receptor (PPARalpha); Somatostatin analogues
Abstract :
[en] PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas. METHODS: Tumours from 51 acromegalic patients were characterized for PPARalpha and AIP expression by immunohistochemistry (IHC) and/or Real Time RT-PCR. Data were analysed according to tumour characteristics and pre-operative treatment with somatostatin analogues (SSA). The effects of fenofibrate were studied in GH3 cells in vitro. RESULTS: PPARalpha was expressed in most somatotropinomas. A modest relationship was found between PPARalpha and AIP expression, both being significantly higher in the presence of pre-operative SSA. However, only AIP expression was influenced by the response to treatment. Dual effects of fenofibrate were observed in GH3 cells, consisting of cell growth inhibition and an increase in GH secretion inhibited by octreotide. CONCLUSIONS: PPARalpha is a new player in somatotropinomas. Potential interactions between PPARalpha agonists and SSA may deserve further investigation.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Rotondi, Sandra
Modarelli, Alessio
Oliva, Maria-Antonietta
ROSTOMYAN, Liliya  
Sanita, Patrizia
Ventura, Luca
Daly, Adrian  ;  Université de Liège > Département des sciences cliniques > Endocrinologie
Esposito, Vincenzo
Angelucci, Adriano
Arcella, Antonietta
Giangaspero, Felice
Beckers, Albert ;  Université de Liège > Département des sciences cliniques > Endocrinologie
Jaffrain-Rea, Marie-Lise
More authors (3 more) Less
Language :
English
Title :
Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH cells.
Publication date :
2016
Journal title :
Molecular and Cellular Endocrinology
ISSN :
0303-7207
eISSN :
1872-8057
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
Available on ORBi :
since 25 March 2016

Statistics


Number of views
73 (12 by ULiège)
Number of downloads
47 (10 by ULiège)

Scopus citations®
 
1
Scopus citations®
without self-citations
0
OpenCitations
 
0

Bibliography


Similar publications



Contact ORBi