Article (Scientific journals)
Haemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency
SID, Sélim; Dugauquier, Christophe; DE PRIJCK, Bernard et al.
2015In Belgian Journal of Hematology, 6 (2), p. 74-78
Peer Reviewed verified by ORBi
 

Files


Full Text
347.pdf
Publisher postprint (357.86 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Burkitt’s lymphoma; Glucose-6-phosphate dehydrogenase deficiency; rasburicase
Abstract :
[en] We present a patient with Burkitt's lymphoma who suffered a severe haemolytic crisis after treatment with rasburicase. This case report underlines the high incidence of glucose-6-phosphate dehydrogenase deficiency in some ethnic groups and the importance of a detailed patient and family history before starting treatment, even in case of emergency. Glucose-6-phosphate dehydrogenase is an essential enzyme since it makes the synthesis of NADPH + H from NADP possible, which determines the reducing power (NADPH) of the cell. Every defect in this physiological process, notably glucose-6-phosphate dehydrogenase deficiency, may thus result simultaneously with the use of rasburicase in acute or chronic haemolysis according to the importance of the deficiency. Management is based on stopping the incriminated drug and on supportive therapy consisting of administering packed red blood cells if the anaemia is poorly tolerated.
Disciplines :
Hematology
Author, co-author :
SID, Sélim ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Dugauquier, Christophe
DE PRIJCK, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
BONNET, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Beguin, Yves  ;  Université de Liège > GIGA-R : Hématologie
Language :
English
Title :
Haemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency
Publication date :
2015
Journal title :
Belgian Journal of Hematology
ISSN :
2033-3749
Publisher :
Ariez Medical Publishing, Amsterdam, Netherlands
Volume :
6
Issue :
2
Pages :
74-78
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2016

Statistics


Number of views
70 (7 by ULiège)
Number of downloads
149 (3 by ULiège)

Bibliography


Similar publications



Contact ORBi