The right dorsal premotor mosaic: organization, functions, and connectivity

[en] The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions.

Disciplines :

Neurosciences & behavior

Author, co-author :

Genon, Sarah ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Li, Hai

Fan, Lingzhong

Müller, Veronika I.

Cieslik, Edna C.

Hoffstaedter, Felix

Reid, Andrew T.

Langner, Robert

Grefkes, Christian

Fox, Peter T.

More authors (5 more)

Language :

English

Title :

The right dorsal premotor mosaic: organization, functions, and connectivity

Publication date :

2017

Journal title :

Cerebral Cortex

ISSN :

1047-3211

eISSN :

1460-2199

Publisher :

Oxford University Press, Cary, United States - North Carolina

Volume :

Issue :

Pages :

2095-2110

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 February 2016

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