Article (Scientific journals)
Drug-polymer electrostatic complexes as new structuring agents for the formation of drug-loaded ordered mesoporous silica
Molina, Emilie; Warnant, Jérôme; Mathonnat, Mélody et al.
2015In Langmuir, 31 (47), p. 12839-12844
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Keywords :
biomaterial
Abstract :
[en] Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behaviour was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors and, this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multi-step processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Molina, Emilie;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Warnant, Jérôme;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier > University of Liège (ULg), Department of Chemistry, Center for Education and Research on Macromolecules (CERM)
Mathonnat, Mélody;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Bathfield, Maël;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
In, Martin;  University of Montpellier, Laboratory Charles Coulomb, UMR 5221 CNRS
Laurencin, Danielle;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lacroix-Desmazes, Patrick;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Marcotte, Nathalie;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Gérardin, Corine;  Institut Charles Gerhardt, UMR 5253 CNRS, Montpellier
Language :
English
Title :
Drug-polymer electrostatic complexes as new structuring agents for the formation of drug-loaded ordered mesoporous silica
Publication date :
01 December 2015
Journal title :
Langmuir
ISSN :
0743-7463
eISSN :
1520-5827
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
31
Issue :
47
Pages :
12839-12844
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 February 2016

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