small angle neutron scattering (SANS); membrane; cyclodextrin; cholesterol
Abstract :
[en] The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC) liposomes doped with cholesterol. From the modelling of the experimental neutron scattering crosssections, the detailed response of the vesicle structure upon addition of increasing amounts of RAMEB up to 30 mM has been assessed. This study has been performed below and above the DMPC bilayer phase transition temperature and shows that cholesterol extraction by RAMEB is linked to a decrease of the average radius and of the aggregation number of the vesicles. This extraction takes place in a dose-dependent way until a more monodisperse population of cholesterol-free liposomes was obtained. In addition, the bilayer thickness evolution was inferred, as well as the liposome coverage by RAMEB.
Research Center/Unit :
Molecular Dynamics Laboratory
Disciplines :
Chemistry
Author, co-author :
Joset, Arnaud ; Université de Liège > Centre d'études et de rech. sur les macromolécules (CERM)
Grammenos, Angeliki
Hoebeke, Maryse ; Université de Liège > Département de physique > Spectroscopie biomédicale
Leyh, Bernard ; Université de Liège > Département de chimie (sciences) > Laboratoire de dynamique moléculaire
Language :
English
Title :
Small-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin
Publication date :
January 2016
Journal title :
Journal of Inclusion Phenomena and Macrocyclic Chemistry
ISSN :
1388-3127
eISSN :
1573-1111
Publisher :
Springer
Volume :
84
Issue :
1
Pages :
153-161
Peer reviewed :
Peer reviewed
Funders :
the NMI3 network funded by the European Commission
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