Small-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin

Joset, Arnaud; Grammenos, Angeliki; Hoebeke, Maryse; Leyh, Bernard

doi:10.1007/s10847-015-0592-x

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Small-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin

Joset, Arnaud; Grammenos, Angeliki; Hoebeke, Maryse et al.

2016 • In Journal of Inclusion Phenomena and Macrocyclic Chemistry, 84 (1), p. 153-161

Peer reviewed

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https://hdl.handle.net/2268/192289

DOI
10.1007/s10847-015-0592-x

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Keywords :

small angle neutron scattering (SANS); membrane; cyclodextrin; cholesterol

Abstract :

[en] The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC) liposomes doped with cholesterol. From the modelling of the experimental neutron scattering crosssections, the detailed response of the vesicle structure upon addition of increasing amounts of RAMEB up to 30 mM has been assessed. This study has been performed below and above the DMPC bilayer phase transition temperature and shows that cholesterol extraction by RAMEB is linked to a decrease of the average radius and of the aggregation number of the vesicles. This extraction takes place in a dose-dependent way until a more monodisperse population of cholesterol-free liposomes was obtained. In addition, the bilayer thickness evolution was inferred, as well as the liposome coverage by RAMEB.

Research Center/Unit :

Molecular Dynamics Laboratory

Disciplines :

Chemistry

Author, co-author :

Joset, Arnaud ; Université de Liège > Centre d'études et de rech. sur les macromolécules (CERM)

Grammenos, Angeliki

Hoebeke, Maryse ; Université de Liège > Département de physique > Spectroscopie biomédicale

Leyh, Bernard ; Université de Liège > Département de chimie (sciences) > Laboratoire de dynamique moléculaire

Language :

English

Title :

Small-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin

Publication date :

January 2016

Journal title :

Journal of Inclusion Phenomena and Macrocyclic Chemistry

ISSN :

1388-3127

eISSN :

1573-1111

Publisher :

Springer

Volume :

Issue :

Pages :

153-161

Peer reviewed :

Peer reviewed

Funders :

the NMI3 network funded by the European Commission

Available on ORBi :

since 26 January 2016

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