Reference : MacroH2A in stem cells: a story beyond gene repression.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
MacroH2A in stem cells: a story beyond gene repression.
Creppe, Catherine mailto [IMPPC - Badalona > Chromatin and Cell Fate > > >]
Posavec, Melanija [> >]
Douet, Julien [> >]
Buschbeck, Marcus [> >]
Yes (verified by ORBi)
United Kingdom
[en] Animals ; Cell Differentiation ; Cellular Reprogramming ; Chromatin/metabolism ; Embryonic Development ; Epigenesis, Genetic ; Histones/antagonists & inhibitors/genetics/metabolism ; Humans ; Mice ; Mutation ; RNA Interference ; RNA, Small Interfering/metabolism ; Stem Cells/cytology/metabolism ; Zebrafish
[en] The importance of epigenetic mechanisms is most clearly illustrated during early development when a totipotent cell goes through multiple cell fate transitions to form the many different cell types and tissues that constitute the embryo and the adult. The exchange of a canonical H2A histone for the 'repressive' macroH2A variant is one of the most striking epigenetic chromatin alterations that can occur at the level of the nucleosome. Here, we discuss recent data on macroH2A in zebrafish and mouse embryos, in embryonic and adult stem cells and also in nuclear reprogramming. We highlight the role of macroH2A in the establishment and maintenance of differentiated states and we discuss its still poorly recognized function in transcriptional activation.

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