Elongator: an ancestral complex driving transcription and migration through protein acetylation.

Acetylation; Animals; Cell Movement/physiology; Histone Acetyltransferases/genetics/metabolism/physiology; Histones/metabolism; Humans; Mice; Nerve Tissue Proteins/genetics/metabolism/physiology; Neurodegenerative Diseases/genetics/metabolism; Transcription, Genetic; Tubulin/metabolism

Abstract :

[en] Elongator is an evolutionary highly conserved complex. At least two of its cellular functions rely on the intrinsic lysine acetyl-transferase activity of the elongator complex. Its two known substrates--histone H3 and alpha-tubulin--reflect the different roles of elongator in the cytosol and the nucleus. A picture seems to emerge in which nuclear elongator could regulate the transcriptional elongation of a subset of stress-inducible genes through acetylation of histone H3 in the promoter-distal gene body. In the cytosol, elongator-mediated acetylation of alpha-tubulin contributes to intracellular trafficking and cell migration. Defects in both functions of elongator have been implicated in neurodegenerative disorders.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Creppe, Catherine ; Université de Liège - ULiège

Buschbeck, Marcus

Language :

English

Title :

Elongator: an ancestral complex driving transcription and migration through protein acetylation.

Publication date :

12 January 2011

Journal title :

Journal of Biomedicine and Biotechnology

ISSN :

1110-7243

eISSN :

1110-7251

Publisher :

Hindawi Publishing Corporation, Egypt

Volume :

2011

Pages :

924898

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 January 2016

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