Article (Scientific journals)
VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study
Berghmans, Thierry; Lafitte, Jean-Jacques; Scherpereel, Arnaud et al.
2015In ERJ Open Research, 1 (2)
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Abstract :
[en] Salvage chemotherapy (CT) for relapsing or refractory small cell lung cancer (SCLC) remains disappointing. In vitro experiments showed that valproic acid increases apoptosis of SCLC cell lines exposed to doxorubicin, vindesine and bis(2-chloroethyl)amine. The primary objective of this phase II study was to determine whether epigenetic modulation with valproic acid in addition to a doxorubicin, vindesine and cyclophosphamide (VAC) regimen improves 6-month progression-free survival (PFS). Patients with pathologically proven SCLC refractory to prior platinum derivatives and etoposide were eligible. After central registration, patients received VAC plus daily oral valproic acid. 64 patients were registered, of whom six were ineligible. Seven patients did not receive any CT, leaving 51 patients assessable for the primary end-point. The objective response rate was 19.6%. Median PFS was 2.8 months (95% CI 2.5–3.6 months) and 6-month PFS was 6%. Median survival time was 5.9 months (95% CI 4.7–7.5 months). Toxicity was mainly haematological, with 88% and 26% grade 3–4 neutropenia and thrombopenia, respectively. Despite an interesting response rate, the addition of valproic acid to VAC did not translate into adequate PFS in relapsing SCLC or SCLC refractory to platinum–etoposide.
Disciplines :
Author, co-author :
Berghmans, Thierry
Lafitte, Jean-Jacques
Scherpereel, Arnaud
Ameye, Lieveke
Paesmans, Marianne
Meert, Anne-Pascale
Colinet, Benoit
Tulippe, Christian
Willems, Luc  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Leclercq, Nathalie
Sculier, Jean-Paul
Language :
Title :
VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study
Publication date :
19 October 2015
Journal title :
ERJ Open Research
Publisher :
European Respiratory Society, Sheffield, United Kingdom
Volume :
Issue :
Peer reviewed :
Peer Reviewed verified by ORBi
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