Article (Scientific journals)
PHARMACOGENOMIQUE ET MEDECINE PERSONNALISEE : VERS UN SCREENING SYSTEMATIQUE DE LA POPULATION ?
DIDEBERG, Vinciane; SEGERS, Karin; KOOPMANSCH, Benjamin et al.
2015In Revue Médicale de Liège, 70 (5-6), p. 251-6
 

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Keywords :
Biomarkers, Pharmacological/analysis; Dideoxynucleosides/therapeutic use; Dihydropyrimidine Dehydrogenase Deficiency/diagnosis/genetics; Drug Hypersensitivity/diagnosis/genetics; Genetic Testing/trends/utilization; Glucuronosyltransferase/deficiency/genetics; HLA-B Antigens/genetics; Humans; Individualized Medicine/methods/trends; Neoplasms/genetics/therapy; Pharmacogenetics/methods; Purine-Pyrimidine Metabolism, Inborn Errors/diagnosis/genetics
Abstract :
[en] Recent advances in medical genomics open new perspectives for personalized medicine through the identification of genetic variants that influence drug response and/or the risk of side effects. Today, the clinical applications of pharmacogenetics remain scarce as a consequence of the cost and turn-around-time of genetic tests. However, a few tests are recommended, for instance before the prescription of some anti-cancer agents or the anti-retroviral agent abacavir. In the future, we will probably move either towards rapid targeted tests or towards a large screening, before any diagnosis, of all the genetic factors influencing the therapeutic response. In that case, physicians will have to consult the patient genomic data before drug prescription in order to personalize the choice of the therapeutic agent or its dosage. However, such a genomic approach brings economical and ethical questions and will require further progress in our capacity to interpret and store the personal genomic data without compromising their confidentiality.
Disciplines :
Genetics & genetic processes
Author, co-author :
DIDEBERG, Vinciane ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
SEGERS, Karin ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
KOOPMANSCH, Benjamin ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
LAMBERT, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Bours, Vincent ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Language :
French
Title :
PHARMACOGENOMIQUE ET MEDECINE PERSONNALISEE : VERS UN SCREENING SYSTEMATIQUE DE LA POPULATION ?
Alternative titles :
[en] PHARMACOGENOMICS AND PERSONALIZED MEDICINE: TOWARDS A SYSTEMATIC GENOMIC SCREENING?
Publication date :
2015
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
70
Issue :
5-6
Pages :
251-6
Available on ORBi :
since 11 January 2016

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