Anderson, D. J. (2001). Stem cells and pattern formation in the nervous system: the possible versus the actual. Neuron 30, 19-35. doi: 10.1016/S0896-6273(01)00260-4.
Andreu-Agulló, C., Morante-Redolat, J. M., Delgado, A. C., and Fariñas, I. (2009). Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat. Neurosci. 12, 1514-1523. doi: 10.1038/nn.2437.
Andrews, E. M., Tsai, S. Y., Johnson, S. C., Farrer, J. R., Wagner, J. P., Kopen, G. C., et al. (2008). Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat. Exp. Neurol. 211, 588-592. doi: 10.1016/j.expneurol.2008.02.027.
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970. doi: 10.1038/nm747.
Bacigaluppi, M., Pluchino, S., Peruzzotti-Jametti, L., Kilic, E., Kilic, U., Salani, G., et al. (2009). Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 132, 2239-2251. doi: 10.1093/brain/awp174.
Bao, X., Wei, J., Feng, M., Lu, S., Li, G., Dou, W., et al. (2011). Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res. 1367, 103-113. doi: 10.1016/j.brainres.2010.10.063.
Bao, X. J., Liu, F. Y., Lu, S., Han, Q., Feng, M., Wei, J. J., et al. (2013). Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. Int. J. Mol. Med. 31, 1087-1096. doi: 10.3892/ijmm.2013.1290.
Barkho, B. Z., Munoz, A. E., Li, X., Li, L., Cunningham, L. A., and Zhao, X. (2008). Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells 26, 3139-3149. doi: 10.1634/stemcells.2008-0519.
Barkho, B. Z., and Zhao, X. (2011). Adult neural stem cells: response to stroke injury and potential for therapeutic applications. Curr. Stem Cell Res. Ther. 6, 327-338. doi: 10.2174/157488811797904362.
Bauer, S., Hay, M., Amilhon, B., Jean, A., and Moyse, E. (2005). In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem. Neuroscience 130, 75-90. doi: 10.1016/j.neuroscience.2004.08.047.
Bédard, A., Gravel, C., and Parent, A. (2006). Chemical characterization of newly generated neurons in the striatum of adult primates. Exp. Brain Res. 170, 501-512. doi: 10.1007/s00221-005-0233-5.
Ben-David, U., and Benvenisty, N. (2011). The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat. Rev. Cancer 11, 268-277. doi: 10.1038/nrc3034.
Benner, E. J., Luciano, D., Jo, R., Abdi, K., Paez-Gonzalez, P., Sheng, H., et al. (2013). Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature 497, 369-373. doi: 10.1038/nature12069.
Bennett, L., Yang, M., Enikolopov, G., and Iacovitti, L. (2009). Circumventricular organs: a novel site of neural stem cells in the adult brain. Mol. Cell. Neurosci. 41, 337-347. doi: 10.1016/j.mcn.2009.04.007.
Bernier, P. J., Bedard, A., Vinet, J., Levesque, M., and Parent, A. (2002). Newly generated neurons in the amygdala and adjoining cortex of adult primates. Proc. Natl. Acad. Sci. U.S.A. 99, 11464-11469. doi: 10.1073/pnas.172403999.
Braun, R. G., Andrews, E. M., and Kartje, G. L. (2012). Kinematic analysis of motor recovery with human adult bone marrow-derived somatic cell therapy in a rat model of stroke. Neurorehabil. Neural Repair 26, 898-906. doi: 10.1177/1545968312446004.
Bühnemann, C., Scholz, A., Bernreuther, C., Malik, C. Y., Braun, H., Schachner, M., et al. (2006). Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain 129, 3238-3248. doi: 10.1093/brain/awl261.
Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., et al. (2009). Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat. Neurosci. 12, 259-267. doi: 10.1038/nn.2268.
Carleton, A., Petreanu, L. T., Lansford, R., Alvarez-Buylla, A., and Lledo, P. M. (2003). Becoming a new neuron in the adult olfactory bulb. Nat. Neurosci. 6, 507-518. doi: 10.1038/nn1048.
Cayre, M., Courtès, S., Martineau, F., Giordano, M., Arnaud, K., Zamaron, A., et al. (2013). Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination. Development 140, 3107-3117. doi: 10.1242/dev.092999.
Charrier, C., Coronas, V., Fombonne, J., Roger, M., Jean, A., Krantic, S., et al. (2006). Characterization of neural stem cells in the dorsal vagal complex of adult rat by in vivo proliferation labeling and in vitro neurosphere assay. Neuroscience 138, 5-16. doi: 10.1016/j.neuroscience.2005.10.046.
Chen, J., Li, Y., Wang, L., Lu, M., Zhang, X., and Chopp, M. (2001a). Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J. Neurol. Sci. 189, 49-57. doi: 10.1016/S0022-510X(01)00557-3.
Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., et al. (2001b). Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32, 1005-1011. doi: 10.1161/01.STR.32.4.1005s.
Chen, J., Zacharek, A., Zhang, C., Jiang, H., Li, Y., Roberts, C., et al. (2005). Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J. Neurosci. 25, 2366-2375. doi: 10.1523/JNEUROSCI.5071-04.2005.
Chen, Z. Z., Jiang, X. D., Zhang, L. L., Shang, J. H., Du, M. X., Xu, G., et al. (2008). Beneficial effect of autologous transplantation of bone marrow stromal cells and endothelial progenitor cells on cerebral ischemia in rabbits. Neurosci. Lett. 445, 36-41. doi: 10.1016/j.neulet.2008.08.039.
Chou, J., Harvey, B. K., Chang, C. F., Shen, H., Morales, M., and Wang, Y. (2006). Neuroregenerative effects of BMP7 after stroke in rats. J. Neurol. Sci. 240, 21-29. doi: 10.1016/j.jns.2005.08.015.
Chu, K., Park, K. I., Lee, S. T., Jung, K. H., Ko, S. Y., Kang, L., et al. (2005). Combined treatment of vascular endothelial growth factor and human neural stem cells in experimental focal cerebral ischemia. Neurosci. Res. 53, 384-390. doi: 10.1016/j.neures.2005.08.010.
Corbett, A. M., Sieber, S., Wyatt, N., Lizzi, J., Flannery, T., Sibbit, B., et al. (2015). Increasing neurogenesis with fluoxetine, simvastatin and ascorbic acid leads to functional recovery in ischemic stroke. Recent Pat. Drug Deliv. Formul. 9, 158-166. doi: 10.2174/1872211309666150122102846.
Cui, X., Chen, J., Zacharek, A., Li, Y., Roberts, C., Kapke, A., et al. (2007). Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke. Stem Cells 25, 2777-2785. doi: 10.1634/stemcells.2007-0169.
Daadi, M. M., Maag, A. L., and Steinberg, G. K. (2008). Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. PLoS ONE 3:e1644. doi: 10.1371/journal.pone.0001644.
Darsalia, V., Allison, S. J., Cusulin, C., Monni, E., Kuzdas, D., Kallur, T., et al. (2011). Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J. Cereb. Blood Flow Metab. 31, 235-242. doi: 10.1038/jcbfm.2010.81.
Dayer, A. G., Cleaver, K. M., Abouantoun, T., and Cameron, H. A. (2005). New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. J. Cell Biol. 168, 415-427. doi: 10.1083/jcb.200407053.
del Zoppo, G., Ginis, I., Hallenbeck, J. M., Iadecola, C., Wang, X., and Feuerstein, G. Z. (2000). Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 10, 95-112. doi: 10.1111/j.1750-3639.2000.tb00247.x.
del Zoppo, G. J., Milner, R., Mabuchi, T., Hung, S., Wang, X., Berg, G. I., et al. (2007). Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 38, 646-651. doi: 10.1161/01.STR.0000254477.34231.cb.
Dempsey, R. J., Sailor, K. A., Bowen, K. K., Türeyen, K., and Vemuganti, R. (2003). Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF. J. Neurochem. 87, 586-597. doi: 10.1046/j.1471-4159.2003.02022.x.
Drago, D., Cossetti, C., Iraci, N., Gaude, E., Musco, G., Bachi, A., et al. (2013). The stem cell secretome and its role in brain repair. Biochimie 95, 2271-2285. doi: 10.1016/j.biochi.2013.06.020.
Duan, C. L., Liu, C. W., Shen, S. W., Yu, Z., Mo, J. L., Chen, X. H., et al. (2015). Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury. Glia 63, 1660-1670. doi: 10.1002/glia.22837.
Eckert, A., Huang, L., Gonzalez, R., Kim, H. S., Hamblin, M. H., and Lee, J. P. (2015). Bystander Effect fuels human induced pluripotent stem cell-derived neural stem cells to quickly attenuate early stage neurological deficits after stroke. Stem Cells Transl. Med. 4, 841-851. doi: 10.5966/sctm.2014-0184.
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nat. Med. 4, 1313-1317. doi: 10.1038/3305.
Faiz, M., Sachewsky, N., Gascón, S., Bang, K. W. A., Morshead, C. M., and Nagy, A. (2015). Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke. Cell Stem Cell 17, 1-11. doi: 10.1016/j.stem.2015.08.002.
Furube, E., Morita, M., and Miyata, S. (2015). Characterization of neural stem cells and their progeny in the sensory circumventricular organs of adult mouse. Cell Tissue Res. 362, 347-365. doi: 10.1007/s00441-015-2201-0.
Gage, F. H. (2000). Mammalian neural stem cells. Science 287, 1433-1438. doi: 10.1126/science.287.5457.1433.
Genin, E. C., Caron, N., Vandenbosch, R., Nguyen, L., and Malgrange, B. (2014). Concise review: forkhead pathway in the control of adult neurogenesis. Stem Cells 32, 1398-1407. doi: 10.1002/stem.1673.
Ginsberg, M. D., and Busto, R. (1989). Rodent models of cerebral ischemia. Stroke 20, 1627-1642. doi: 10.1161/01.STR.20.12.1627.
Goldberg, J. S., and Hirschi, K. K. (2009). Diverse roles of the vasculature within the neural stem cell niche. Regen. Med. 4, 879-897. doi: 10.2217/rme.09.61.
Gonzalez-Perez, O., Quiñones-Hinojosa, A., and Garcia-Verdugo, J. M. (2010). Immunological control of adult neural stem cells. J. Stem Cells 5, 23-31.
Grade, S., Weng, Y. C., Snapyan, M., Kriz, J., Malva, J. O., and Saghatelyan, A. (2013). Brain-derived neurotrophic factor promotes vasculature-associated migration of neuronal precursors toward the ischemic striatum. PLoS ONE 8:e55039. doi: 10.1371/journal.pone.0055039.
Gu, W., Brännström, T., and Wester, P. (2000). Cortical neurogenesis in adult rats after reversible photothrombotic stroke. J. Cereb. Blood Flow Metab. 20, 1166-1173. doi: 10.1097/00004647-200008000-00002.
Gutiérrez-Fernández, M., Rodríguez-Frutos, B., Alvarez-Grech, J., Vallejo-Cremades, M. T., Expósito-Alcaide, M., Merino, J., et al. (2011). Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats. Neuroscience 175, 394-405. doi: 10.1016/j.neuroscience.2010.11.054.
Hassani, Z., O'Reilly, J., Pearse, Y., Stroemer, P., Tang, E., Sinden, J., et al. (2012). Human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke. PLoS ONE 7:e50444. doi: 10.1371/journal.pone.0050444.
Hayashi, T., Noshita, N., Sugawara, T., and Chan, P. H. (2003). Temporal profile of angiogenesis and expression of related genes in the brain after ischemia. J. Cereb. Blood Flow Metab. 23, 166-180. doi: 10.1097/00004647-200302000-00004.
Heinrich, C., Bergami, M., Gascón, S., Lepier, A., Viganò, F., Dimou, L., et al. (2014). Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Rep. 3, 1000-1014. doi: 10.1016/j.stemcr.2014.10.007.
Hermann, D. M., Peruzzotti-Jametti, L., Schlechter, J., Bernstock, J. D., Doeppner, T. R., and Pluchino, S. (2014). Neural precursor cells in the ischemic brain-integration, cellular crosstalk, and consequences for stroke recovery. Front. Cell. Neurosci. 8:291. doi: 10.3389/fncel.2014.00291.
Hoehn, B. D., Palmer, T. D., and Steinberg, G. K. (2005). Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 36, 2718-2724. doi: 10.1161/01.STR.0000190020.30282.cc.
Honma, T., Honmou, O., Iihoshi, S., Harada, K., Houkin, K., Hamada, H., et al. (2006). Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp. Neurol. 199, 56-66. doi: 10.1016/j.expneurol.2005.05.004.
Horita, Y., Honmou, O., Harada, K., Houkin, K., Hamada, H., and Kocsis, J. D. (2006). Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat. J. Neurosci. Res. 84, 1495-1504. doi: 10.1002/jnr.21056.
Hossmann, K. A. (2012). The two pathophysiologies of focal brain ischemia: implications for translational stroke research. J. Cereb. Blood Flow Metab. 32, 1310-1316. doi: 10.1038/jcbfm.2011.186.
Hou, S. W., Wang, Y. Q., Xu, M., Shen, D. H., Wang, J. J., Huang, F., et al. (2008). Functional integration of newly generated neurons into striatum after cerebral ischemia in the adult rat brain. Stroke 39, 2837-2844. doi: 10.1161/STROKEAHA.107.510982.
Hwang, I. K., Yoo, K. Y., Park, S. K., An, S. J., Lee, J. Y., Choi, S. Y., et al. (2004). Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult. Neurochem. Int. 45, 149-156. doi: 10.1016/j.neuint.2003.10.006.
Iadecola, C., and Anrather, J. (2011). The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796-808. doi: 10.1038/nm.2399.
Imai, F., Suzuki, H., Oda, J., Ninomiya, T., Ono, K., Sano, H., et al. (2007). Neuroprotective effect of exogenous microglia in global brain ischemia. J. Cereb. Blood Flow Metab. 27, 488-500. doi: 10.1038/sj.jcbfm.9600362.
Iosif, R. E., Ahlenius, H., Ekdahl, C. T., Darsalia, V., Thored, P., Jovinge, S., et al. (2008). Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1. J. Cereb. Blood Flow Metab. 28, 1574-1587. doi: 10.1038/jcbfm.2008.47.
Itokazu, Y., Kitada, M., Dezawa, M., Mizoguchi, A., Matsumoto, N., Shimizu, A., et al. (2006). Choroid plexus ependymal cells host neural progenitor cells in the rat. Glia 53, 32-42. doi: 10.1002/glia.20255.
Jensen, M. B., Yan, H., Krishnaney-Davison, R., Al Sawaf, A., and Zhang, S. C. (2013). Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model. J. Stroke Cerebrovasc. Dis. 22, 304-308. doi: 10.1016/j.jstrokecerebrovasdis.2011.09.008.
Jiang, M., Lv, L., Ji, H., Yang, X., Zhu, W., Cai, L., et al. (2011). Induction of pluripotent stem cells transplantation therapy for ischemic stroke. Mol. Cell. Biochem. 354, 67-75. doi: 10.1007/s11010-011-0806-5.
Jiang, Q., Ewing, J. R., Zhang, Z. G., Zhang, R. L., Hu, J., Divine, G. W., et al. (2001). Magnetization transfer MRI: application to treatment of middle cerebral artery occlusion in rat. J. Magn. Reson. Imaging 13, 178-184. doi: 10.1002/1522-2586(200102)13:2<178::AID-JMRI1027>3.0.CO;2-D.
Jiang, Q., Zhang, Z. G., Ding, G. L., Silver, B., Zhang, L., Meng, H., et al. (2006). MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage 32, 1080-1089. doi: 10.1016/j.neuroimage.2006.05.025.
Jin, K., Minami, M., Lan, J. Q., Mao, X. O., Batteur, S., Simon, R. P., et al. (2001). Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. U.S.A. 98, 4710-4715. doi: 10.1073/pnas.081011098.
Jin, K., Sun, Y., Xie, L., Peel, A., Mao, X. O., Batteur, S., et al. (2003). Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol. Cell. Neurosci. 24, 171-189. doi: 10.1016/S1044-7431(03)00159-3.
Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W., Wang, Y., et al. (2006). Evidence for stroke-induced neurogenesis in the human brain. Proc. Natl. Acad. Sci. U.S.A. 103, 13198-13202. doi: 10.1073/pnas.0603512103.
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., and Greenberg, D. A. (2002). Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 99, 11946-11950. doi: 10.1073/pnas.182296499.
Jin, Q., Cheng, J., Liu, Y., Wu, J., Wang, X., Wei, S., et al. (2014). Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav. Immun. 40, 131-142. doi: 10.1016/j.bbi.2014.03.003.
Joly, J. S., Osório, J., Alunni, A., Auger, H., Kano, S., and Rétaux, S. (2007). Windows of the brain: towards a developmental biology of circumventricular and other neurohemal organs. Semin. Cell Dev. Biol. 18, 512-524. doi: 10.1016/j.semcdb.2007.06.001.
Jones, T. A., and Adkins, D. L. (2015). Motor system reorganization after stroke: stimulating and training toward perfection. Physiology 30, 358-370. doi: 10.1152/physiol.00014.2015.
Kalladka, D., and Muir, K. W. (2014). Brain repair: cell therapy in stroke. Stem Cells Cloning 7, 31-44. doi: 10.2147/SCCAA.S38003.
Kang, S. K., Lee, D. H., Bae, Y. C., Kim, H. K., Baik, S. Y., and Jung, J. S. (2003). Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp. Neurol. 183, 355-366. doi: 10.1016/S0014-4886(03)00089-X.
Karow, M., Sánchez, R., Schichor, C., Masserdotti, G., Ortega, F., Heinrich, C., et al. (2012). Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell 11, 471-476. doi: 10.1016/j.stem.2012.07.007.
Kawai, H., Yamashita, T., Ohta, Y., Deguchi, K., Nagotani, S., Zhang, X., et al. (2010). Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. J. Cereb. Blood Flow Metab. 30, 1487-1493. doi: 10.1038/jcbfm.2010.32.
Kee, N. J., Preston, E., and Wojtowicz, J. M. (2001). Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Exp. Brain Res. 136, 313-320. doi: 10.1007/s002210000591.
Kim, B. J., Kim, M. J., Park, J. M., Lee, S. H., Kim, Y. J., Ryu, S., et al. (2009). Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat. J. Neurol. Sci. 279, 70-75. doi: 10.1016/j.jns.2008.12.025.
Kim, Y. R., Kim, H. N., Ahn, S. M., Choi, Y. H., Shin, H. K., and Choi, B. T. (2014). Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia. PLoS ONE 9:e90000. doi: 10.1371/journal.pone.0090000.
Koh, S. H., Kim, K. S., Choi, M. R., Jung, K. H., Park, K. S., Chai, Y. G., et al. (2008). Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats. Brain Res. 1229, 233-248. doi: 10.1016/j.brainres.2008.06.087.
Kojima, T., Hirota, Y., Ema, M., Takahashi, S., Miyoshi, I., Okano, H., et al. (2010). Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells 28, 545-554. doi: 10.1002/stem.306.
Kokaia, Z., and Lindvall, O. (2003). Neurogenesis after ischaemic brain insults. Curr. Opin. Neurobiol. 13, 127-132. doi: 10.1016/S0959-4388(03)00017-5.
Kokaia, Z., Martino, G., Schwartz, M., and Lindvall, O. (2012). Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat. Neurosci. 15, 1078-1087. doi: 10.1038/nn.3163.
Kokoeva, M. V., Yin, H., and Flier, J. S. (2005). Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310, 679-683. doi: 10.1126/science.1115360.
Kokovay, E., Goderie, S., Wang, Y., Lotz, S., Lin, G., Sun, Y., et al. (2010). Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell 7, 163-173. doi: 10.1016/j.stem.2010.05.019.
Kronenberg, G., Gertz, K., Cheung, G., Buffo, A., Kettenmann, H., Götz, M., et al. (2010). Modulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia. Stroke 41, 2944-2949. doi: 10.1161/STROKEAHA.110.583039.
Krupinski, J., Kaluza, J., Kumar, P., Kumar, S., and Wang, J. M. (1994). Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25, 1794-1798. doi: 10.1161/01.STR.25.9.1794.
Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., et al. (2005). Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol. Ther. 11, 96-104. doi: 10.1016/j.ymthe.2004.09.020.
Lacar, B., Herman, P., Platel, J. C., Kubera, C., Hyder, F., and Bordey, A. (2012). Neural progenitor cells regulate capillary blood flow in the postnatal subventricular zone. J. Neurosci. 32, 16435-16448. doi: 10.1523/JNEUROSCI.1457-12.2012.
Lang, B., Liu, H. L., Liu, R., Feng, G. D., Jiao, X. Y., and Ju, G. (2004). Astrocytes in injured adult rat spinal cord may acquire the potential of neural stem cells. Neuroscience 128, 775-783. doi: 10.1016/j.neuroscience.2004.06.033.
Lee, S. H., Jin, K. S., Bang, O. Y., Kim, B. J., Park, S. J., Lee, N. H., et al. (2015). Differential migration of mesenchymal stem cells to ischemic regions after middle cerebral artery occlusion in rats. PLoS ONE 10:e0134920. doi: 10.1371/journal.pone.0134920.
Lee, S. R., Kim, H. Y., Rogowska, J., Zhao, B. Q., Bhide, P., Parent, J. M., et al. (2006). Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J. Neurosci. 26, 3491-3495. doi: 10.1523/JNEUROSCI.4085-05.2006.
Leker, R. R., Soldner, F., Velasco, I., Gavin, D. K., Androutsellis-Theotokis, A., and McKay, R. D. (2007). Long-lasting regeneration after ischemia in the cerebral cortex. Stroke 38, 153-161. doi: 10.1161/01.STR.0000252156.65953.a9.
Le Magueresse, C., Alfonso, J., Bark, C., Eliava, M., Khrulev, S., and Monyer, H. (2012). Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice. Cereb. Cortex 22, 2285-2296. doi: 10.1093/cercor/bhr302.
Li, L., Jiang, Q., Ding, G., Zhang, L., Zhang, Z. G., Li, Q., et al. (2010). Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study. J. Cereb. Blood Flow Metab. 30, 653-662. doi: 10.1038/jcbfm.2009.238.
Li, Y., Chen, J., and Chopp, M. (2002). Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats. J. Neurol. Sci. 193, 137-146. doi: 10.1016/S0022-510X(01)00657-8.
Li, Y., Chopp, M., Chen, J., Wang, L., Gautam, S. C., Xu, Y. X., et al. (2000). Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J. Cereb. Blood Flow Metab. 20, 1311-1319. doi: 10.1097/00004647-200009000-00006.
Lichtenwalner, R. J., and Parent, J. M. (2006). Adult neurogenesis and the ischemic forebrain. J. Cereb. Blood Flow Metab. 26, 1-20. doi: 10.1038/sj.jcbfm.9600170.
Lin, R., Cai, J., Nathan, C., Wei, X., Schleidt, S., Rosenwasser, R., et al. (2015). Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol. Dis. 74, 229-239. doi: 10.1016/j.nbd.2014.11.016.
Lin, R., and Iacovitti, L. (2015). Classic and novel stem cell niches in brain homeostasis and repair. Brain Res. doi: 10.1016/j.brainres.2015.04.029. [Epub ahead of print].
Liu, F., You, Y., Li, X., Ma, T., Nie, Y., Wei, B., et al. (2009). Brain injury does not alter the intrinsic differentiation potential of adult neuroblasts. J. Neurosci. 29, 5075-5087. doi: 10.1523/JNEUROSCI.0201-09.2009.
Liu, X. S., Chopp, M., Zhang, R. L., and Zhang, Z. G. (2013). MicroRNAs in cerebral ischemia-induced neurogenesis. J. Neuropathol. Exp. Neurol. 72, 718-722. doi: 10.1097/NEN.0b013e31829e4963.
Liu, X. S., Zhang, Z. G., Zhang, R. L., Gregg, S., Morris, D. C., Wang, Y., et al. (2007). Stroke induces gene profile changes associated with neurogenesis and angiogenesis in adult subventricular zone progenitor cells. J. Cereb. Blood Flow Metab. 27, 564-574. doi: 10.1038/sj.jcbfm.9600371.
Lo, E. H. (2008). A new penumbra: transitioning from injury into repair after stroke. Nat. Med. 14, 497-500. doi: 10.1038/nm1735.
Luo, C. X., Jiang, J., Zhou, Q. G., Zhu, X. J., Wang, W., Zhang, Z. J., et al. (2007). Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. J. Neurosci. Res. 85, 1637-1646. doi: 10.1002/jnr.21317.
Luzzati, F., De Marchis, S., Fasolo, A., and Peretto, P. (2006). Neurogenesis in the caudate nucleus of the adult rabbit. J. Neurosci. 26, 609-621. doi: 10.1523/JNEUROSCI.4371-05.2006.
Magavi, S. S., Leavitt, B. R., and Macklis, J. D. (2000). Induction of neurogenesis in the neocortex of adult mice. Nature 405, 951-955. doi: 10.1038/35016083.
Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M., Lindvall, O., et al. (2014). A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science 346, 237-241. doi: 10.1126/science.346.6206.237.
Marin, O., Anderson, S. A., and Rubenstein, J. L. (2000). Origin and molecular specification of striatal interneurons. J. Neurosci. 20, 6063-6076.
Martino, G., and Pluchino, S. (2006). The therapeutic potential of neural stem cells. Nat. Rev. Neurosci. 7, 395-406. doi: 10.1038/nrn1908.
Martino, G., Pluchino, S., Bonfanti, L., and Schwartz, M. (2011). Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol. Rev. 91, 1281-1304. doi: 10.1152/physrev.00032.2010.
Matarredona, E. R., Murillo-Carretero, M., Moreno-López, B., and Estrada, C. (2005). Role of nitric oxide in subventricular zone neurogenesis. Brain Res. Brain Res. Rev. 49, 355-366. doi: 10.1016/j.brainresrev.2005.01.001.
Michelucci, A., Bithell, A., Burney, M. J., Johnston, C. E., Wong, K. Y., Teng, S. W., et al. (2015). The neurogenic potential of astrocytes is regulated by inflammatory signals. Mol. Neurobiol. doi: 10.1007/s12035-015-9296-x. [Epub ahead of print].
Migaud, M., Batailler, M., Segura, S., Duittoz, A., Franceschini, I., and Pillon, D. (2010). Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones. Eur. J. Neurosci. 32, 2042-2052. doi: 10.1111/j.1460-9568.2010.07521.x.
Mine, Y., Tatarishvili, J., Oki, K., Monni, E., Kokaia, Z., and Lindvall, O. (2013). Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats. Neurobiol. Dis. 52, 191-203. doi: 10.1016/j.nbd.2012.12.006.
Mirzadeh, Z., Han, Y. G., Soriano-Navarro, M., García-Verdugo, J. M., and Alvarez-Buylla, A. (2010). Cilia organize ependymal planar polarity. J. Neurosci. 30, 2600-2610. doi: 10.1523/JNEUROSCI.3744-09.2010.
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., and Alvarez-Buylla, A. (2008). Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell 3, 265-278. doi: 10.1016/j.stem.2008.07.004.
Mobley, A. K., Tchaicha, J. H., Shin, J., Hossain, M. G., and McCarty, J. H. (2009). Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J. Cell Sci. 122, 1842-1851. doi: 10.1242/jcs.043257.
Morrison, S. J. (2001). Neuronal potential and lineage determination by neural stem cells. Curr. Opin. Cell Biol. 13, 666-672. doi: 10.1016/S0955-0674(00)00269-6.
Moskowitz, M. A., Lo, E. H., and Iadecola, C. (2010). The science of stroke: mechanisms in search of treatments. Neuron 67, 181-198. doi: 10.1016/j.neuron.2010.07.002.
Nakagomi, T., Kubo, S., Nakano-Doi, A., Sakuma, R., Lu, S., Narita, A., et al. (2015). Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells. Stem Cells 33, 1962-1974. doi: 10.1002/stem.1977.
Nakagomi, T., Molnár, Z., Nakano-Doi, A., Taguchi, A., Saino, O., Kubo, S., et al. (2011). Ischemia-induced neural stem/progenitor cells in the pia mater following cortical infarction. Stem Cells Dev. 20, 2037-2051. doi: 10.1089/scd.2011.0279.
Nishijima, T., Piriz, J., Duflot, S., Fernandez, A. M., Gaitan, G., Gomez-Pinedo, U., et al. (2010). Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 67, 834-846. doi: 10.1016/j.neuron.2010.08.007.
Ohab, J. J., Fleming, S., Blesch, A., and Carmichael, S. T. (2006). A neurovascular niche for neurogenesis after stroke. J. Neurosci. 26, 13007-13016. doi: 10.1523/JNEUROSCI.4323-06.2006.
Ohira, K., Furuta, T., Hioki, H., Nakamura, K. C., Kuramoto, E., Tanaka, Y., et al. (2010). Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat. Neurosci. 13, 173-179. doi: 10.1038/nn.2473.
Oki, K., Tatarishvili, J., Wood, J., Koch, P., Wattananit, S., Mine, Y., et al. (2012). Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 30, 1120-1133. doi: 10.1002/stem.1104.
Okun, E., Griffioen, K. J., Lathia, J. D., Tang, S. C., Mattson, M. P., and Arumugam, T. V. (2009). Toll-like receptors in neurodegeneration. Brain Res. Rev. 59, 278-292. doi: 10.1016/j.brainresrev.2008.09.001.
Panchision, D. M. (2009). The role of oxygen in regulating neural stem cells in development and disease. J. Cell. Physiol. 220, 562-568. doi: 10.1002/jcp.21812.
Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., and Ferriero, D. M. (2002). Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol. 52, 802-813. doi: 10.1002/ana.10393.
Pencea, V., Bingaman, K. D., Wiegand, S. J., and Luskin, M. B. (2001). Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci. 21, 6706-6717.
Pérez-Martín, M., Cifuentes, M., Grondona, J. M., López-Avalos, M. D., Gómez-Pinedo, U., García-Verdugo, J. M., et al. (2010). IGF-I stimulates neurogenesis in the hypothalamus of adult rats. Eur. J. Neurosci. 31, 1533-1548. doi: 10.1111/j.1460-9568.2010.07220.x.
Pierce, A. A., and Xu, A. W. (2010). De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J. Neurosci. 30, 723-730. doi: 10.1523/JNEUROSCI.2479-09.2010.
Plane, J. M., Whitney, J. T., Schallert, T., and Parent, J. M. (2008). Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke. Exp. Neurol. 214, 125-134. doi: 10.1016/j.expneurol.2008.08.006.
Prass, K., Scharff, A., Ruscher, K., Löwl, D., Muselmann, C., Victorov, I., et al. (2003). Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 34, 1981-1986. doi: 10.1161/01.STR.0000080381.76409.B2.
Price, C. J., Hoyda, T. D., and Ferguson, A. V. (2008). The area postrema: a brain monitor and integrator of systemic autonomic state. Neuroscientist 14, 182-194. doi: 10.1177/1073858407311100.
Robel, S., Berninger, B., and Götz, M. (2011). The stem cell potential of glia: lessons from reactive gliosis. Nat. Rev. Neurosci. 12, 88-104. doi: 10.1038/nrn2978.
Robin, A. M., Zhang, Z. G., Wang, L., Zhang, R. L., Katakowski, M., Zhang, L., et al. (2006). Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 26, 125-134. doi: 10.1038/sj.jcbfm.9600172.
Rojczyk-Golebiewska, E., Palasz, A., and Wiaderkiewicz, R. (2014). Hypothalamic subependymal niche: a novel site of the adult neurogenesis. Cell. Mol. Neurobiol. 34, 631-642. doi: 10.1007/s10571-014-0058-5.
Ruan, G. P., Han, Y. B., Wang, T. H., Xing, Z. G., Zhu, X. B., Yao, X., et al. (2013). Comparative study among three different methods of bone marrow mesenchymal stem cell transplantation following cerebral infarction in rats. Neurol. Res. 35, 212-220. doi: 10.1179/1743132812Y.0000000152.
Ruan, L., Wang, B., ZhuGe, Q., and Jin, K. (2015). Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Res. 1623, 166-173. doi: 10.1016/j.brainres.2015.02.042.
Ruscher, K., Freyer, D., Karsch, M., Isaev, N., Megow, D., Sawitzki, B., et al. (2002). Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J. Neurosci. 22, 10291-10301.
Saaltink, D. J., Håvik, B., Verissimo, C. S., Lucassen, P. J., and Vreugdenhil, E. (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. J. Comp. Neurol. 520, 2805-2823. doi: 10.1002/cne.23144.
Saha, B., Peron, S., Murray, K., Jaber, M., and Gaillard, A. (2013). Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury. Stem Cell Res. 11, 965-977. doi: 10.1016/j.scr.2013.06.006.
Sanin, V., Heeß, C., Kretzschmar, H. A., and Schüller, U. (2013). Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia. Neuropathol. Appl. Neurobiol. 39, 510-518. doi: 10.1111/j.1365-2990.2012.01301.x.
Sawada, M., Matsumoto, M., and Sawamoto, K. (2014). Vascular regulation of adult neurogenesis under physiological and pathological conditions. Front. Neurosci. 8:53. doi: 10.3389/fnins.2014.00053.
Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., and Kiefer, R. (2003). Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp. Neurol. 183, 25-33. doi: 10.1016/S0014-4886(03)00082-7.
Shapiro, L. A., Ng, K., Zhou, Q. Y., and Ribak, C. E. (2009). Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. Epilepsy Behav. 14(Suppl. 1), 74-80. doi: 10.1016/j.yebeh.2008.09.011.
Sharp, F. R., Liu, J., and Bernabeu, R. (2002). Neurogenesis following brain ischemia. Brain Res. Dev. Brain Res. 134, 23-30. doi: 10.1016/S0165-3806(01)00286-3.
Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N., et al. (2004). Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338-1340. doi: 10.1126/science.1095505.
Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S. M., Goderie, S. K., et al. (2008). Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3, 289-300. doi: 10.1016/j.stem.2008.07.026.
Sims, J. R., Lee, S. W., Topalkara, K., Qiu, J., Xu, J., Zhou, Z., et al. (2009). Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke 40, 3618-3626. doi: 10.1161/STROKEAHA.109.561951.
Smith, E. J., Stroemer, R. P., Gorenkova, N., Nakajima, M., Crum, W. R., Tang, E., et al. (2012). Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke. Stem Cells 30, 785-796. doi: 10.1002/stem.1024.
Song, M., Kim, Y. J., Kim, Y. H., Roh, J., Kim, S. U., and Yoon, B. W. (2011). Effects of duplicate administration of human neural stem cell after focal cerebral ischemia in the rat. Int. J. Neurosci. 121, 457-461. doi: 10.3109/00207454.2011.576792.
Sun, C., Sun, H., Wu, S., Lee, C. C., Akamatsu, Y., Wang, R. K., et al. (2013). Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway. J. Neurosci. 33, 17314-17325. doi: 10.1523/JNEUROSCI.2129-13.2013.
Sun, F., Wang, X., Mao, X., Xie, L., and Jin, K. (2012). Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice. PLoS ONE 7:e46326. doi: 10.1371/journal.pone.0046326.
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., et al. (2003). VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111, 1843-1851. doi: 10.1172/JCI200317977.
Suyama, S., Sunabori, T., Kanki, H., Sawamoto, K., Gachet, C., Koizumi, S., et al. (2012). Purinergic signaling promotes proliferation of adult mouse subventricular zone cells. J. Neurosci. 32, 9238-9247. doi: 10.1523/JNEUROSCI.4001-11.2012.
Taguchi, A., Soma, T., Tanaka, H., Kanda, T., Nishimura, H., Yoshikawa, H., et al. (2004). Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest. 114, 330-338. doi: 10.1172/JCI200420622.
Takasawa, K., Kitagawa, K., Yagita, Y., Sasaki, T., Tanaka, S., Matsushita, K., et al. (2002). Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 22, 299-307. doi: 10.1097/00004647-200203000-00007.
Tang, Y., Wang, J., Lin, X., Wang, L., Shao, B., Jin, K., et al. (2014). Neural stem cell protects aged rat brain from ischemia-reperfusion injury through neurogenesis and angiogenesis. J. Cereb. Blood Flow Metab. 34, 1138-1147. doi: 10.1038/jcbfm.2014.61.
Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., et al. (2008). A specialized vascular niche for adult neural stem cells. Cell Stem Cell 3, 279-288. doi: 10.1016/j.stem.2008.07.025.
Teramoto, T., Qiu, J., Plumier, J. C., and Moskowitz, M. A. (2003). EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. J. Clin. Invest. 111, 1125-1132. doi: 10.1172/JCI200317170.
Thored, P., Arvidsson, A., Cacci, E., Ahlenius, H., Kallur, T., Darsalia, V., et al. (2006). Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 24, 739-747. doi: 10.1634/stemcells.2005-0281.
Thored, P., Heldmann, U., Gomes-Leal, W., Gisler, R., Darsalia, V., Taneera, J., et al. (2009). Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia 57, 835-849. doi: 10.1002/glia.20810.
Thored, P., Wood, J., Arvidsson, A., Cammenga, J., Kokaia, Z., and Lindvall, O. (2007). Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke 38, 3032-3039. doi: 10.1161/STROKEAHA.107.488445.
Tonchev, A. B., Yamashima, T., Sawamoto, K., and Okano, H. (2005). Enhanced proliferation of progenitor cells in the subventricular zone and limited neuronal production in the striatum and neocortex of adult macaque monkeys after global cerebral ischemia. J. Neurosci. Res. 81, 776-788. doi: 10.1002/jnr.20604.
Torper, O., Ottosson, D. R., Pereira, M., Lau, S., Cardoso, T., Grealish, S., et al. (2015). In vivo reprogramming of striatal NG2 glia into functional neurons that integrate into local host circuitry. Cell Rep. 12, 474-481. doi: 10.1016/j.celrep.2015.06.040.
Tsai, P. T., Ohab, J. J., Kertesz, N., Groszer, M., Matter, C., Gao, J., et al. (2006). A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J. Neurosci. 26, 1269-1274. doi: 10.1523/JNEUROSCI.4480-05.2006.
Türeyen, K., Vemuganti, R., Bowen, K. K., Sailor, K. A., and Dempsey, R. J. (2005). EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain. Neurosurgery 57, 1254-1263. doi: 10.1227/01.neu.0000186040.96929.8a.
Turnley, A. M., Basrai, H. S., and Christie, K. J. (2014). Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells? Front. Neurosci. 8:29. doi: 10.3389/fnins.2014.00029.
Wang, L., Chopp, M., Zhang, R. L., Zhang, L., Letourneau, Y., Feng, Y. F., et al. (2009). The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke. Neuroscience 158, 1356-1363. doi: 10.1016/j.neuroscience.2008.10.064.
Wang, X., Mao, X., Xie, L., Sun, F., Greenberg, D. A., and Jin, K. (2012). Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice. PLoS ONE 7:e38932. doi: 10.1371/journal.pone.0038932.
Wang, Y., Chen, X., Cao, W., and Shi, Y. (2014). Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat. Immunol. 15, 1009-1016. doi: 10.1038/ni.3002.
Wanner, I. B., Anderson, M. A., Song, B., Levine, J., Fernandez, A., Gray-Thompson, Z., et al. (2013). Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J. Neurosci. 33, 12870-12886. doi: 10.1523/JNEUROSCI.2121-13.2013.
Wei, L. C., Shi, M., Chen, L. W., Cao, R., Zhang, P., and Chan, Y. S. (2002). Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice. Brain Res. Dev. Brain Res. 139, 9-17. doi: 10.1016/S0165-3806(02)00509-6.
Wiltrout, C., Lang, B., Yan, Y., Dempsey, R. J., and Vemuganti, R. (2007). Repairing brain after stroke: a review on post-ischemic neurogenesis. Neurochem. Int. 50, 1028-1041. doi: 10.1016/j.neuint.2007.04.011.
Woodruff, T. M., Thundyil, J., Tang, S. C., Sobey, C. G., Taylor, S. M., and Arumugam, T. V. (2011). Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol. Neurodegener. 6:11. doi: 10.1186/1750-1326-6-11.
Xu, Y., Tamamaki, N., Noda, T., Kimura, K., Itokazu, Y., Matsumoto, N., et al. (2005). Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp. Neurol. 192, 251-264. doi: 10.1016/j.expneurol.2004.12.021.
Yagita, Y., Kitagawa, K., Ohtsuki, T., Takasawa, K.-i., Miyata, T., Okano, H., et al. (2001). Neurogenesis by progenitor cells in the ischemic adult rat hippocampus. Stroke 32, 1890-1896. doi: 10.1161/01.STR.32.8.1890.
Yamashita, T., Ninomiya, M., Hernandez Acosta, P., Garcia-Verdugo, J. M., Sunabori, T., Sakaguchi, M., et al. (2006). Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J. Neurosci. 26, 6627-6636. doi: 10.1523/JNEUROSCI.0149-06.2006.
Yan, Y. P., Sailor, K. A., Lang, B. T., Park, S. W., Vemuganti, R., and Dempsey, R. J. (2007). Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 27, 1213-1224. doi: 10.1038/sj.jcbfm.9600432.
Yan, Y. P., Sailor, K. A., Vemuganti, R., and Dempsey, R. J. (2006). Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation. Eur. J. Neurosci. 24, 45-54. doi: 10.1111/j.1460-9568.2006.04872.x.
Yang, Z., Covey, M. V., Bitel, C. L., Ni, L., Jonakait, G. M., and Levison, S. W. (2007). Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Ann. Neurol. 61, 199-208. doi: 10.1002/ana.21068.
Yenari, M. A., Kauppinen, T. M., and Swanson, R. A. (2010). Microglial activation in stroke: therapeutic targets. Neurotherapeutics 7, 378-391. doi: 10.1016/j.nurt.2010.07.005.
Yu, T. S., Washington, P. M., and Kernie, S. G. (2014). Injury-induced neurogenesis: mechanisms and relevance. Neuroscientist. doi: 10.1177/1073858414563616. [Epub ahead of print].
Yuan, J. (2009). Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis 14, 469-477. doi: 10.1007/s10495-008-0304-8.
Yuan, T., Liao, W., Feng, N. H., Lou, Y. L., Niu, X., Zhang, A. J., et al. (2013). Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurologic function in a rat model of middle cerebral artery occlusion. Stem Cell Res. Ther. 4, 73. doi: 10.1186/scrt224.
Zhang, R., Zhang, Z., Zhang, C., Zhang, L., Robin, A., Wang, Y., et al. (2004). Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J. Neurosci. 24, 5810-5815. doi: 10.1523/JNEUROSCI.1109-04.2004.
Zhang, R. L., Chopp, M., Roberts, C., Liu, X., Wei, M., Nejad-Davarani, S. P., et al. (2014). Stroke increases neural stem cells and angiogenesis in the neurogenic niche of the adult mouse. PLoS ONE 9:e113972. doi: 10.1371/journal.pone.0113972.
Zhang, R. L., LeTourneau, Y., Gregg, S. R., Wang, Y., Toh, Y., Robin, A. M., et al. (2007). Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone. J. Neurosci. 27, 3157-3162. doi: 10.1523/JNEUROSCI.4969-06.2007.
Zhang, R. L., Zhang, Z. G., Zhang, L., and Chopp, M. (2001). Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience 105, 33-41. doi: 10.1016/S0306-4522(01)00117-8.
Zhang, Z. G., and Chopp, M. (2009). Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 8, 491-500. doi: 10.1016/S1474-4422(09)70061-4.
Zhu, D. Y., Liu, S. H., Sun, H. S., and Lu, Y. M. (2003). Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J. Neurosci. 23, 223-229.
