Reference : Contribution a l'etude des effets perturbateurs endocriniens des polluants environnem...
Reports : Other
Human health sciences : Laboratory medicine & medical technology
Contribution a l'etude des effets perturbateurs endocriniens des polluants environnementaux
[en] Effects of Environmental Pollutants on Hormone Disturbances
Charlier, Corinne mailto [Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique]
[en] endocrine disruptors
[en] There is an increasing scientific concern that organochlorine compounds, recognized as environmental pollutants, may cause estrogen-related disorders. One of the main hypotheses is that organochlorines can act through their estrogenic or anti-estrogenic properties. Many endocrine diseases can be concerned by the pathogenic role on environmental residues in their promotion. The carcinogenic potential of environmental xenoestrogens on breast cancer is a matter of controversy. In Europe, despite their prohibition since the 70's, residues persist in soil and rivers, resulting in a widespread contamination of the general population. Our results suggest that environmental exposure to p,p'-DDE, HCB or PCBS may contribute to multifactorial pathogenesis of breast cancer. Male infertility is also a matter of concern. Our data suggest that male infertility can be associated with exposure of the mothers to p,p'-DDE, and that deleterious effects are probably restricted to intra-uterine life. Early or precocious puberty in children adopted from developing countries where organochlorines are still used is frequently reported. A possible relationship with exposure to DDT is suggested. There are two possible pathways to account for precocious puberty following chronic exposure to estrogenic related compounds: weak stimulation of estrogen sensitive tissues or removal in Belgium of the suppressing effects of estrogens on gonadotrophins, suppressing effect that was due to exposure in the origin country.
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