Reference : [18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced ...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Oncology
Human health sciences : Gastroenterology & hepatology
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/189038
[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
English
WITHOFS, Nadia mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
Martinive, Philippe mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
VANDERICK, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiothérapie >]
BLETARD, Noëlla mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
SCAGNOL, Irène mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Mievis, Frédéric mailto [Université de Liège > > Centre de recherches du cyclotron >]
Giacomelli, Fabrice mailto [Université de Liège > > Centre de recherches du cyclotron >]
Coucke, Philippe mailto [Université de Liège > Département des sciences cliniques > Radiothérapie >]
Delvenne, Philippe mailto [Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Cataldo, Didier mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Gambhir, Sanjiv S. [> >]
HUSTINX, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
2016
European Journal of Nuclear Medicine and Molecular Imaging
Yes (verified by ORBi)
International
1619-7070
1619-7089
[en] Angiogenesis ; Integrin ; PET ; RGD ; Rectal cancer
[en] PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use.
http://hdl.handle.net/2268/189038
10.1007/s00259-015-3219-y

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