Available on ORBi since
07 December 2015
Article (Scientific journals)
Identification of clinical parameters predictive of one-year survival using two geriatric tools in clinically fit older patients with hematological malignancies: Major impact of cognition
Dubruille, Stéphanie; Libert, Yves; Roos, Myriam et al.
2015 • In Journal of Geriatric Oncology, 6 (5), p. 362-369
Peer Reviewed verified by ORBi
 

Files


Full Text
2015 Dubruille Stéphanie-BJH .pdf
Publisher postprint (212.46 kB)
Full Text Parts
2015 Dubruille Stéphanie- BJH Fig 2.pdf
Publisher postprint (44.46 kB)
2015 Dubruille Stéphanie- BJH fig1.pdf
Publisher postprint (36.41 kB)
2015 Dubruille Stéphanie- BJH Table 1.pdf
Publisher postprint (63.94 kB)
2015 Dubruille Stéphanie- BJH Table 2.pdf
Publisher postprint (59.31 kB)
2015 Dubruille Stéphanie- BJH Table 3.pdf
Publisher postprint (69.28 kB)
2015 Dubruille Stéphanie- BJH Table 4.pdf
Publisher postprint (53.92 kB)

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Geriatric assessment; Cognitive impairment; Hematological malignancy; Elderly
Abstract :
[en] Background Little is known about the reliability of G8 screening tool and the prognostic value of clinical parameters within the Comprehensive Geriatric Assessment (CGA) in clinically fit older patients with hematological malignancies. Materials and Methods This study was performed to assess the reliability of G8 as a screening tool and to determine the predictive value of CGA items in terms of 1-year overall survival (OS). G8 and CGA were proposed to 107 consecutive patients (65–89 years) with hematological malignancies assessed by their physicians as clinically fit, meaning not exhibiting geriatric syndromes and/or irreversible comorbidities significantly impairing their daily function, and thus able to receive chemotherapy. Results Out of 107 patients, 90 patients were evaluable and completed both scales; 72% and 80% were defined as “vulnerable” when evaluated with G8 (≤14.5) or CGA (≥2 impairments) respectively. The area under ROC-curve of G8 compared to CGA was 0.749 ± 0.051. Neither G8 nor CGA total scores were predictive of 1-year OS. However, age (HR = 1.105, 95% CI: 1.016–1.202; p = 0.019), diagnosis (HR = 5.208, 95% CI: 1.895–14.310; p = 0.001) and cognitive status (HR = 3.260, 95% CI: 1.043–10.194; p = 0.042) were predictive of OS. Conclusions We conclude that in our selected hematological patients: 1) the G8 score does not help selecting patients for CGA, 2) the G8 and CGA total scores do not predict OS, and 3) in addition to the age and disease itself, cognitive impairment appears to be a powerful prognostic factor.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Dubruille, Stéphanie;  Université de Bruxelles
Libert, Yves;  Université de Bruxelles
Roos, Myriam
Vandenbossche, Sandrine
Collard, Aurélie
Meuleman, Nathalie
Maerevoet, Marie
Etienne, Anne-Marie  ;  Université de Liège > Département de Psychologie > Psychologie de la santé
Reynaert, Christine
Razavi, Darius;  Université de Bruxelles
Bron, Dominique
Language :
English
Title :
Identification of clinical parameters predictive of one-year survival using two geriatric tools in clinically fit older patients with hematological malignancies: Major impact of cognition
Alternative titles :
[en] Identification of clinical parameters predictive of one-year survival using two geriatric tools in clinically fit older patients with hematological malignancies: Major impact of cognition
Publication date :
2015
Journal title :
Journal of Geriatric Oncology
ISSN :
1879-4068
eISSN :
1879-4076
Publisher :
Elsevier
Volume :
6
Issue :
5
Pages :
362-369
Peer reviewed :
Peer Reviewed verified by ORBi

Statistics


Number of views
164 (2 by ULiège)
Number of downloads
400 (0 by ULiège)

Scopus citations®
 
41
Scopus citations®
without self-citations
34
OpenCitations
 
36

Bibliography


Similar publications



Contact ORBi