tumour immunity and irradiation; immunity and radiotherapy; active specific immunotherapy; abscopal effect; bystander effect; immunité anti-tumorale et irradiation; immunité et radiothérapie tumorale; abscopal effet
Abstract :
[en] Immunological effects on CBA mice grafted with Sarcoma J were studied after tumour irradiation by gamma rays. Rejection rate of a second sarcoma graft was used as in vivo measure of anti-tumour immunity.Radiotherapy boosts the auto-immune reaction of the host against its growing tumour. Cured animals reject the test graft proportionnally to the curative dose. As compared to surgery, high doses of radiations induce a better anti-tumour immunity. An active specific immunotherapy markedly increases the tumour response to radiotherapy. Moreover the therapeutic association confers to the cured animals a maximum degree of specific immunity. [fr] Les réactions immunologiques de souris CBA ayant reçu une greffe de Sarcome J ont été étudiées après irradiation tumorale par rayons gamma. Le taux de rejet d'un second greffon tumoral a été utilisé comme mesure in vivo de l'immunité anti-tumorale. La radiothérapie augmente la réaction auto-immune de l'hôte contre sa tumeur en croissance. Les animaux guéris rejettent la greffe test proportionnellement à l'importance de la dose curatrice. Par comparaison avec la chirurgie, de hautes doses de radiations induisent une meilleure immunité anti-tumorale. Une immunothérapie active spécifique augmente la réponse tumorale à la radiothérapie. De plus, cette association thérapeutique confère aux animaux guéris un degré d'immunité spécifique maximal.
Disciplines :
Oncology
Author, co-author :
Deneufbourg, Jean-Marie ; Université de Liège ; Faculté de Médecine ; Assistant > Hôpital universitaire de Bavière - Liège > Service de Radiothérapie (Pr Closon)
Language :
French
Title :
Radiothérapie tumorale et status immunitaire de l'hôte dans un système allogénique
Alternative titles :
[en] Tumour radiotherapy and immune status of the host in an allogenic system
Publication date :
January 1972
Journal title :
Bulletin du Cancer
ISSN :
0007-4551
eISSN :
1769-6917
Publisher :
Masson, Paris, France
Volume :
59
Issue :
1
Pages :
61-76
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Mémoire de radiothérapie expérimentale présenté pour l'obtention du titre universitaire de Médecin-Spécialiste en Radiothérapie. Université de Liège (Belgium) juin 1971 : mention Très Bien.
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