Reference : Unravelling the intra-familial correlations and heritability of tumor types in MEN1, ...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/187636
Unravelling the intra-familial correlations and heritability of tumor types in MEN1, a GTE study.
English
Thevenon, Julien [> >]
Bourredjem, Abderrahmane [> >]
Faivre, Laurence [> >]
Bauters, Catherine [> >]
Calender, Alain [> >]
Lebras, Maelle [> >]
Giraud, Sophie [> >]
Niccoli, Patricia [> >]
Odou, Marie-Francoise [> >]
Borson-Chazot, Francoise [> >]
Barlier, Anne [> >]
Lombard-Bohas, Catherine [> >]
Clauser, Eric [> >]
Tabarin, Antoine [> >]
Pasmant, Eric [> >]
Chabre, Olivier [> >]
CASTERMANS, Emilie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Ruszniewski, Philippe [> >]
Bertherat, Jerome [> >]
Delemer, Brigitte [> >]
Christin-Maitre, Sophie [> >]
Beckers, Albert mailto [Université de Liège > Département des sciences cliniques > Endocrinologie >]
Guilhem, Isabelle [> >]
Rohmer, Vincent [> >]
Goichot, Bernard [> >]
Caron, Philippe [> >]
Baudin, Eric [> >]
Chanson, Philippe [> >]
Groussin, Lionel [> >]
Du Boullay, Helene [> >]
Weryha, Georges [> >]
Lecomte, Pierre []
Schillo, Franck [> >]
Bihan, Helene [> >]
Archambeaud, Francoise [> >]
Kerlan, Veronique [> >]
Bourcigaux, Nathalie [> >]
Kuhn, Jean-Marc [> >]
Verges, Bruno [> >]
Rodier, Michel [> >]
Renard, Michel [> >]
Sadoul, Jean Louis [> >]
Binquet, Christine [> >]
Goudet, Pierre [> >]
2015
European journal of endocrinology / European Federation of Endocrine Societies
173
6
819-826
Yes (verified by ORBi)
International
0804-4643
1479-683X
[en] BACKGROUND: Multiple Endocrine Neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Most studies demonstrated the absence of direct genotype-phenotype correlations. The existence of a higher risk of death in the GTE-cohort associated with a mutations in the JunD interacting domain, suggests heterogeneity across families in disease expressivity. This study aims to assess the existence of modifying genetic factors by estimating the intra-familial correlations and heritability of the six main tumor types in MEN1. METHODS: The study included 797 patients from 265 kindred and studied seven phenotypic criteria: parathyroid and pancreatic neuroendocrine tumors (NETs), pituitary, adrenal, bronchial and thymic tumors (ThNETs) and the presence of metastasis. Intra-familial correlations and heritability estimates were calculated from family tree data using specific validated statistical analysis software. RESULTS: Intra-familial correlations were significant and decreased along parental degrees distance for pituitary, adrenal and th-NETs. The heritability of these three tumor types was consistently strong and significant with 64% (Standard Error [SE]=0.13; p < 0.001) for pituitary tumor, 65% (SE=0,21; p < 0.001) for adrenal tumors, and 97% (SE=0.41; p=0.006) for thNETs. CONCLUSION: The present study shows the existence of modifying genetic factors for thymus, adrenal and pituitary MEN1 tumor types. The identification of at-risk subgroups of individuals within cohorts is the first step towards personalization of care. Next generation sequencing on this subset of tumors will help identify the molecular basis of MEN1 variable genetic expressivity.
http://hdl.handle.net/2268/187636

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