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A Comparative Study of the Antimycotic Activity of a Miconazole Hp-Beta Cyclodextrin Solution and a Surfactant Solution
Piel, Géraldine; Hayette, Marie-Pierre; Evrard, Brigitte et al.
1999In Journal de Pharmacie de Belgique, 54 (3, May-Jun), p. 87-8
 

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Abstract :
[en] The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market probably because of the toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing 10 mg of miconazole per ml (as the marketed solution), in combination with HP-beta cyclodextrin and lactic acid. The MIC of these two solutions were determined by broth microdilution method (following the NCCLS guidelines) against 15 yeasts and 16 filamentous fungi isolates. This study showed that MIC obtained with these two solutions are not significantly different. In vitro, the cyclodextrin solution has the same antimycotic activity as the Daktarin IV solution and can be proposed as a safe and effective parenteral solution to replace the previous surfactant solution.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Van Hees, Thierry ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
A Comparative Study of the Antimycotic Activity of a Miconazole Hp-Beta Cyclodextrin Solution and a Surfactant Solution
Publication date :
1999
Event name :
Forum des Sciences Pharmaceutiques
Event organizer :
Société Belge des Sciences Pharmaceutiques
Event place :
Spa, Belgium
Audience :
International
Journal title :
Journal de Pharmacie de Belgique
ISSN :
0047-2166
Publisher :
Association Pharmaceutique Belge, Belgium
Volume :
54
Issue :
3, May-Jun
Pages :
87-8
Available on ORBi :
since 14 August 2009

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