Article (Scientific journals)
Protomyofibroblast Pathway in Early Thermal Burn Healing
Hermanns-Lê, Trinh; Pierard, Gérald; jennes, Serge et al.
2015In Skin Pharmacology and Physiology, 28, p. 250-254
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Keywords :
Burn injury; Myofibroblast; Wound healing; Protomyofibroblast; Skin
Abstract :
[en] Wound healing following partial thickness thermal burns is commonly hampered by the risk of hypertrophic scarring. Skin myofibroblast (MF) density is commonly increased in postburn healing. The transition between fibroblast-like cells and α-smooth muscle actin (SMA)+ MF possibly begins with CD14+ monocytes, evolving to CD14+ CD34+ fibrocytes, followed by β-SMA+ protomyofibroblast (PMF) maturation. Skin biopsies from 25 burn patients were collected about 1 and 4 weeks after injury. Immunohistochemistry was performed using monoclonal antibodies to α-SMA, β-SMA, factor XIIIa, lysozyme, Mac 387, CD14, CD117 and Ulex europaeus agglutinin-1 (UEA-1). The set of Mac 387+ and CD14+ monocytes was accompanied by both CD34+ fibrocytes and factor XIIIa+ dendrocytes. By contrast, β-SMA+ PMF were rare. Of note, α-SMA+ MF were more abundant at week 4 than at week 1 (p < 0.01). The UEA-1+ endothelial cells showed marked variations in their dermal distribution, irrespective of the densities in the other scrutinized cells. In conclusion, healing of partial thickness thermal burns involves a diversity of cell types including PMF. In the present samples, the PMF density remained low.
Disciplines :
Dermatology
Author, co-author :
Hermanns-Lê, Trinh ;  Regional Hospital, Huy > Department of Dermatology
Pierard, Gérald ;  Université de Liège > Department of Dermatopathology > Labic laboratory
jennes, Serge;  Queen Astrid Military Hospital, Neder-over-Heembeek > Burn Unit,
Franchimont, Claudine ;  Université de Liège > Department of Dermatopathology > LABIC Laboratory
Language :
English
Title :
Protomyofibroblast Pathway in Early Thermal Burn Healing
Publication date :
2015
Journal title :
Skin Pharmacology and Physiology
ISSN :
1660-5527
eISSN :
1660-5535
Publisher :
S. Karger, Basel, Switzerland
Volume :
28
Pages :
250-254
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 October 2015

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