Article (Scientific journals)
Comparative enantiomer affinity pattern of beta-blockers in aqueous and nonaqueous CE using single-component anionic cyclodextrins.
Feng, Ying; Wang, Tingting; Jiang, Zhengjin et al.
2015In Electrophoresis, 36 (11-12), p. 1358-64
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Keywords :
Aqueous and nonaqueous CE; Cyclodextrins (CDs); Enantiomer affinity pattern (EAP); beta-Blockers
Abstract :
[en] A series of eight chiral beta-blocker drugs, acebutolol, atenolol, carazolol, carteolol, carvedilol, propranolol, sotalol, and talinolol, have been enantioseparated using two single-component anionic beta-CD derivatives, namely heptakis (2,3-di-O-methyl-6-sulfo)-beta-CD (HDMS-beta-CD) and heptakis (2,3-di-O-acetyl-6-sulfo)-beta-CD (HDAS-beta-CD), in aqueous CE and NACE. The influence of the nature of substituents (methyl or acetyl) in positions 2 and 3 on the CD derivatives and of the electrophoretic medium (water or methanol) on the enantioselectivity and enantiomer affinity pattern (EAP) of these structurally related compounds was systematically studied. All eight beta-blockers could be enantioseparated at least partially in the four CE systems, except sotalol with HDMS-beta-CD in NACE. In general, lower affinity and enantioselectivity were obtained in the presence of HDMS-beta-CD compared to HDAS-beta-CD. Reversals of EAPs were observed for all compounds. EAPs toward these two CDs were found to be opposite to each other in NACE for all compounds except carvedilol and in aqueous CE for atenolol, carteolol, talinolol, and sotalol. It is particularly noteworthy that opposite EAPs were also observed using the same CD derivative when the aqueous BGE was replaced with the methanolic one: for carazolol, carvedilol, and propranolol in the presence of HDMS-beta-CD and for acebutolol and carvedilol with HDAS-beta-CD.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Feng, Ying
Wang, Tingting
Jiang, Zhengjin
Chankvetadze, Bezhan
Crommen, Jacques ;  Université de Liège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Comparative enantiomer affinity pattern of beta-blockers in aqueous and nonaqueous CE using single-component anionic cyclodextrins.
Publication date :
2015
Journal title :
Electrophoresis
ISSN :
0173-0835
eISSN :
1522-2683
Publisher :
John Wiley & Sons, United Kingdom
Volume :
36
Issue :
11-12
Pages :
1358-64
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available on ORBi :
since 24 October 2015

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