Application of Supercritical Carbon Dioxide for the Preparation of a Piroxicam-Beta-Cyclodextrin Inclusion Compound

[en] PURPOSE: Piroxicam is a poorly soluble NSAID, whose solubility is enhanced when included into beta-cyclodextrin. The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. METHODS: The solubility and the stability of piroxicam in supercritical CO2 were determined. Then, the influence of the temperature, the pressure and the time of exposure on the inclusion rate was studied. RESULTS: The solubility of piroxicam varied over a wide range depending on the temperature and pressure (from 0.006 to 1.500 mg/g of CO2). The temperature and the time of exposure had a great influence on the inclusion yield, while pressure did not and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 15 MPa of CO2. This complex was characterized by Differential Scanning Calorimetry, differential solubility and Fourier Transform Infrared Spectrometry. CONCLUSIONS: Supercritical carbon dioxide may prove to be a novel useful complexation method of drugs into beta-cyclodextrin.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Van Hees, Thierry ; Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique

Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Otte, Xavier

Thunus, Léopold ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Language :

English

Title :

Application of Supercritical Carbon Dioxide for the Preparation of a Piroxicam-Beta-Cyclodextrin Inclusion Compound

Publication date :

December 1999

Journal title :

Pharmaceutical Research

ISSN :

0724-8741

eISSN :

1573-904X

Publisher :

Kluwer Academic/Plenum Publishers, New York, United States - New York

Volume :

Issue :

Pages :

1864-70

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 August 2009

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