Article (Scientific journals)
Ion channel degeneracy enables robust and tunable neuronal firing rates.
Drion, Guillaume; O'Leary, Timothy; Marder, Eve
2015In Proceedings of the National Academy of Sciences of the United States of America
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Keywords :
FI curve; Type I excitability; Type II excitability
Abstract :
[en] Firing rate is an important means of encoding information in the nervous system. To reliably encode a wide range of signals, neurons need to achieve a broad range of firing frequencies and to move smoothly between low and high firing rates. This can be achieved with specific ionic currents, such as A-type potassium currents, which can linearize the frequency-input current curve. By applying recently developed mathematical tools to a number of biophysical neuron models, we show how currents that are classically thought to permit low firing rates can paradoxically cause a jump to a high minimum firing rate when expressed at higher levels. Consequently, achieving and maintaining a low firing rate is surprisingly difficult and fragile in a biological context. This difficulty can be overcome via interactions between multiple currents, implying a need for ion channel degeneracy in the tuning of neuronal properties.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Drion, Guillaume ;  Université de Liège > R&D Direction : Chercheurs ULiège en mobilité
O'Leary, Timothy
Marder, Eve
Language :
English
Title :
Ion channel degeneracy enables robust and tunable neuronal firing rates.
Publication date :
September 2015
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 October 2015

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