[en] Ehlers-Danlos syndrome (EDS) represents a heterogenous group of disorders of the connective tissue structure. Currently, several types are distinguish following a limited set of clinical signs and genetic mutations. However, there is a lack of specificity of most recognized genetic alterations with the current clinical typing. In addition, the criteria from dermatopathology, ultrastructure and biomechanics are not considered. In addition, the establish frontiers are hazardous because a series of anatomo-clinical signs are not considered in the classical EDS concept. The hypermobile type EDS represents an example of the diagnostic uncertainties. It results that guidelines based on evidence-based medecine cannot be established. Only an individual management can be offerted to the concerned patients.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Hermanns-Lê, Trinh ; Université de Liège > Département des sciences cliniques > Dermatopathologie
PIERARD, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
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